Thapa Surendra, Shrestha Bijay, Gurung Santosh K, Giri Ramesh
Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM 87131, USA.
Org Biomol Chem. 2015 May 7;13(17):4816-27. doi: 10.1039/c5ob00200a.
Copper is emerging as a viable catalytic metal for cross-coupling reactions to construct carbon-carbon (C-C) bonds. Recent revelations that Cu-catalysts can execute with high efficacy the cross-couplings of a variety of organometallic reagents, including organomagnesium, organoboron, organosilicon, organoindium and organomanganese, with alkyl, aryl and heteroaryl halides clearly demonstrate the versatility of Cu-based catalytic systems in conducting these reactions. In addition, Cu-catalysts are exhibiting a unique reactivity pattern that allows ligandless cross-coupling for aryl-heteroaryl and heteroaryl-heteroaryl bond formation, a transformation that generally requires special custom-designed ligands with Pd-catalysts. This review summarises early discoveries and subsequent advancements made in the area of Cu-catalysed cross-couplings of organometallic reagents with organohalides to form C-C bonds.
铜正成为一种用于交叉偶联反应以构建碳-碳（C-C）键的可行催化金属。最近有研究表明，铜催化剂能够高效地实现多种有机金属试剂（包括有机镁、有机硼、有机硅、有机铟和有机锰）与烷基、芳基和杂芳基卤化物的交叉偶联，这清楚地证明了铜基催化体系在进行这些反应时的多功能性。此外，铜催化剂展现出一种独特的反应模式，能够实现用于形成芳基-杂芳基和杂芳基-杂芳基键的无配体交叉偶联，而这种转化通常需要使用特殊定制配体的钯催化剂。本综述总结了在铜催化有机金属试剂与有机卤化物交叉偶联以形成C-C键领域的早期发现及后续进展。
