• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

UNIM - 301（一种复方尤那尼配方）对Wistar大鼠的抗炎和抗关节炎活性

Anti-inflammatory and antiarthritic activity of UNIM-301 (a polyherbal unani formulation) in Wistar rats.

作者信息

Singh Surender, Kumar Rohit, Jain Hitesh, Gupta Y K

机构信息

Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Pharmacognosy Res. 2015 Apr-Jun;7(2):188-92. doi: 10.4103/0974-8490.150515.

DOI:10.4103/0974-8490.150515
PMID:25829793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4357970/
Abstract

BACKGROUND

UNIM-301 is a polyherbal formulation used in the Unani system of medicine for the treatment of joint pain and rheumatoid arthritis (RA).

OBJECTIVE

The objective was to evaluate the anti-inflammatory and antiarthritic activity of UNIM-301 in carrageenan-induced paw edema and complete Freund's Adjuvant (CFA) induced arthritis.

MATERIALS AND METHODS

The anti-inflammatory and antiarthritic activity of UNIM-301 was evaluated using carrageenan-induced paw edema and CFA induced animal arthritis models, respectively, in doses of 250, 500, and 1000 mg/kg body weight. Anti-inflammatory activity of UNIM-301 was evaluated using carrageenan-induced paw edema model using a digital plethysmometer. Anti-arthritic activity was evaluated using CFA induced arthritis, and joint sizes were measured at regular intervals using a micrometer screw gauge. Serum was collected and subjected to estimation of pro-inflammatory cytokine. Indomethacin 3 mg/kg body weight) was used as a standard drug in both the models. The acute and chronic toxicity study was carried out to evaluate the safety of the test drug.

RESULTS

UNIM-301 treatment produced a dose-dependent reduction in paw edema and paw thickness in carrageenan-induced paw edema and CFA-induced arthritis, respectively, as compared to control. UNIM 301 also reduced the expression of pro-inflammatory mediator in a dose-dependent manner as compared to control.

CONCLUSION

The result of the present study suggests that anti-inflammatory and anti-arthritic activity of UNIM-301, which might be accredited to inhibitory activity on pro-inflammatory cytokines to its various individual constituents.

摘要

背景

UNIM - 301是一种用于尤纳尼医学体系治疗关节疼痛和类风湿性关节炎（RA）的多草药配方。

目的

目的是评估UNIM - 301在角叉菜胶诱导的爪肿胀和完全弗氏佐剂（CFA）诱导的关节炎中的抗炎和抗关节炎活性。

材料与方法

分别使用角叉菜胶诱导的爪肿胀和CFA诱导的动物关节炎模型，以250、500和1000mg/kg体重的剂量评估UNIM - 301的抗炎和抗关节炎活性。使用数字体积描记器通过角叉菜胶诱导的爪肿胀模型评估UNIM - 301的抗炎活性。使用CFA诱导的关节炎评估抗关节炎活性，并使用千分尺定期测量关节大小。收集血清并进行促炎细胞因子的测定。在两个模型中均使用吲哚美辛（3mg/kg体重）作为标准药物。进行急性和慢性毒性研究以评估受试药物的安全性。

结果

与对照组相比，UNIM - 301治疗分别使角叉菜胶诱导的爪肿胀和CFA诱导的关节炎中的爪肿胀和爪厚度呈剂量依赖性降低。与对照组相比，UNIM 301还以剂量依赖性方式降低了促炎介质的表达。

结论

本研究结果表明，UNIM - 301的抗炎和抗关节炎活性可能归因于其对促炎细胞因子及其各种单个成分的抑制活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b1/4357970/de413018a52a/PR-7-188-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b1/4357970/35c15b063835/PR-7-188-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b1/4357970/be31bc294a65/PR-7-188-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b1/4357970/bd69dbc29a84/PR-7-188-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b1/4357970/6739669330a8/PR-7-188-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b1/4357970/de413018a52a/PR-7-188-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b1/4357970/35c15b063835/PR-7-188-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b1/4357970/be31bc294a65/PR-7-188-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b1/4357970/bd69dbc29a84/PR-7-188-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b1/4357970/6739669330a8/PR-7-188-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b1/4357970/de413018a52a/PR-7-188-g005.jpg

相似文献

1
Anti-inflammatory and antiarthritic activity of UNIM-301 (a polyherbal unani formulation) in Wistar rats.UNIM - 301（一种复方尤那尼配方）对Wistar大鼠的抗炎和抗关节炎活性
Pharmacognosy Res. 2015 Apr-Jun;7(2):188-92. doi: 10.4103/0974-8490.150515.
2
Anti-inflammatory and anti-arthritic activity of aqueous extract of Rosa centifolia in experimental rat models.百叶蔷薇水提取物在实验大鼠模型中的抗炎和抗关节炎活性
Int J Rheum Dis. 2017 Sep;20(9):1072-1078. doi: 10.1111/1756-185X.12625. Epub 2015 Jul 27.
3
In vivo antiarthritic activity of Rosa centifolia L. flower extract.百叶蔷薇花提取物的体内抗关节炎活性。
Ayu. 2015 Jul-Sep;36(3):341-5. doi: 10.4103/0974-8520.182753.
4
Antiarthritic activity of majoon suranjan (a polyherbal Unani formulation) in rat.大鼠中复方苏里南丸（一种复方阿育吠陀制剂）的抗关节炎活性。
Indian J Med Res. 2011 Sep;134(3):384-8.
5
Anti-inflammatory, anti-nociceptive, and anti-psychiatric effects by the rhizomes of Alpinia officinarum on complete Freund's adjuvant-induced arthritis in rats.高良姜根茎对完全弗氏佐剂诱导的大鼠关节炎的抗炎、镇痛和抗精神病作用。
J Ethnopharmacol. 2009 Nov 12;126(2):258-64. doi: 10.1016/j.jep.2009.08.033. Epub 2009 Aug 26.
6
Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid in vivo.标准化石榴皮提取物与标志物化合物鞣花酸的体内抗炎和镇痛活性比较。
J Ethnopharmacol. 2013 Jul 30;148(3):901-8. doi: 10.1016/j.jep.2013.05.040. Epub 2013 Jun 3.
7
Antiarthritic activity of a polyherbal formulation against Freund's complete adjuvant induced arthritis in Female Wistar rats.一种多草药配方对弗氏完全佐剂诱导的雌性Wistar大鼠关节炎的抗关节炎活性。
J Basic Clin Pharm. 2015 Jun;6(3):77-83. doi: 10.4103/0976-0105.160738.
8
A new ursane triterpenoic acid and other potential anti-inflammatory and anti-arthritic constituents from EtOAc extracts of Vitellaria paradoxa stem bark.来自奇异果藤黄茎皮乙酸乙酯提取物中的一种新的乌苏烷三萜酸及其他潜在的抗炎和抗关节炎成分。
J Ethnopharmacol. 2015 Nov 4;174:277-86. doi: 10.1016/j.jep.2015.08.014. Epub 2015 Aug 20.
9
Investigation of the effect of phlomisoside F on complete Freund's adjuvant-induced arthritis.毛地黄苷F对完全弗氏佐剂诱导的关节炎的影响研究。
Exp Ther Med. 2017 Feb;13(2):710-716. doi: 10.3892/etm.2016.3995. Epub 2016 Dec 22.
10
Ipomoea batatas L. Lam. ameliorates acute and chronic inflammations by suppressing inflammatory mediators, a comprehensive exploration using in vitro and in vivo models.Ipomoea batatas L. Lam. 通过抑制炎症介质来改善急性和慢性炎症，采用体外和体内模型进行了全面探讨。
BMC Complement Altern Med. 2018 Jul 13;18(1):216. doi: 10.1186/s12906-018-2279-5.

引用本文的文献

1
Majoon Chobchini attenuates arthritis disease severity and RANKL-mediated osteoclastogenesis in rheumatoid arthritis.乔布奇尼丸减轻类风湿性关节炎的疾病严重程度及RANKL介导的破骨细胞生成。
3 Biotech. 2021 Oct;11(10):436. doi: 10.1007/s13205-021-02985-4. Epub 2021 Sep 17.
2
Ayurvedic Balarista ameliorate anti-arthritic activity in adjuvant induced arthritic rats by inhibiting pro-inflammatory cytokines and oxidative stress.印度草医学的Balarista通过抑制促炎细胞因子和氧化应激，改善佐剂诱导的关节炎大鼠的抗关节炎活性。
J Tradit Complement Med. 2020 May 4;11(3):228-237. doi: 10.1016/j.jtcme.2020.04.006. eCollection 2021 May.
3

本文引用的文献

1
Anti-arthritic activity of ethanolic extract of Tridax procumbens (Linn.) in Sprague Dawley rats.白花臭草乙醇提取物对斯普拉格-道利大鼠的抗关节炎活性
Pharmacognosy Res. 2013 Apr;5(2):113-7. doi: 10.4103/0974-8490.110541.
2
Vitex negundo inhibits cyclooxygenase-2 inflammatory cytokine-mediated inflammation on carrageenan-induced rat hind paw edema.黄荆抑制角叉菜胶诱导的大鼠后爪水肿中环氧合酶-2炎性细胞因子介导的炎症。
Pharmacognosy Res. 2012 Jul;4(3):134-7. doi: 10.4103/0974-8490.99072.
3
Antiarthritic activity of majoon suranjan (a polyherbal Unani formulation) in rat.
Periodontitis increases rheumatic factor serum levels and citrullinated proteins in gingival tissues and alter cytokine balance in arthritic rats.
牙周炎会增加风湿因子血清水平和牙龈组织中的瓜氨酸化蛋白，并改变关节炎大鼠体内的细胞因子平衡。
PLoS One. 2017 Mar 30;12(3):e0174442. doi: 10.1371/journal.pone.0174442. eCollection 2017.
大鼠中复方苏里南丸（一种复方阿育吠陀制剂）的抗关节炎活性。
Indian J Med Res. 2011 Sep;134(3):384-8.
4
Investigation into the anti-inflammatory and antigranuloma activity of Colchicum luteum Baker in experimental models.调查柳兰（Colchicum luteum Baker）在实验模型中的抗炎和抗肉芽肿活性。
Inflammation. 2012 Jun;35(3):881-8. doi: 10.1007/s10753-011-9389-2.
5
Anti-arthritic and disease modifying activity of Terminalia chebula Retz. in experimental models.诃子提取物对实验模型的抗关节炎和疾病修饰作用。
J Pharm Pharmacol. 2010 Dec;62(12):1801-6. doi: 10.1111/j.2042-7158.2010.01193.x. Epub 2010 Oct 4.
6
Evaluation of the disease modifying activity of Colchicum luteum Baker in experimental arthritis.评价秋水仙碱在实验性关节炎中的疾病修饰作用。
J Ethnopharmacol. 2011 Jan 27;133(2):303-7. doi: 10.1016/j.jep.2010.09.027. Epub 2010 Oct 20.
7
Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: An in vivo and in vitro study.睡茄根粉对实验性诱导炎症的免疫调节作用：一项体内和体外研究。
Vascul Pharmacol. 2006 Jun;44(6):406-10. doi: 10.1016/j.vph.2006.01.015. Epub 2006 May 18.
8
CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT.分枝杆菌佐剂诱导大鼠关节炎的化学疗法
Br J Pharmacol Chemother. 1963 Aug;21(1):127-36. doi: 10.1111/j.1476-5381.1963.tb01508.x.
9
Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.角叉菜胶诱导大鼠后爪水肿作为抗炎药物的一种测定方法。
Proc Soc Exp Biol Med. 1962 Dec;111:544-7. doi: 10.3181/00379727-111-27849.
10
Prevalence of the use of unconventional remedies for arthritis in a metropolitan community.大都市社区中关节炎非常规疗法的使用 prevalence
Arthritis Rheum. 1989 Dec;32(12):1604-7. doi: 10.1002/anr.1780321217.