胃肠道混合性内分泌-外分泌肿瘤的早期前体：组织学与分子相关性
Early precursor of mixed endocrine-exocrine tumors of the gastrointestinal tract: histologic and molecular correlations.
作者信息
Bazerbachi Fateh, Kermanshahi Taher R, Monteiro Carmela
机构信息
Department of Medicine, University of Minnesota, Minneapolis, MN.
Department of Pathology and Laboratory Medicine, University of Florida, Jacksonville, FL.
出版信息
Ochsner J. 2015 Spring;15(1):97-101.
BACKGROUND
Mixed endocrine-exocrine tumors display histologic features of endocrine and glandular differentiation. Unlike in collision tumors, the two components are thought to arise from a monoclonal precursor. Evidence from molecular testing supports the monoclonal theory and suggests that the exocrine component may give rise to the endocrine component but not vice versa.
CASE REPORT
We report a case of an adenomatous polyp in the large intestine that had groups of endocrine cells arising from the crypt bases of the adenomatous (exocrine) epithelium. To our knowledge, ours is only the second report of an adenomatous polyp in which groups of microcarcinoid endocrine cells were recognized. The histologic findings in our case correlate with the molecular findings described in mixed endocrine-exocrine tumors.
CONCLUSION
Our description may represent the primordial stage of a mixed endocrine-exocrine neoplasm.
背景
混合性内分泌-外分泌肿瘤具有内分泌和腺性分化的组织学特征。与碰撞瘤不同，这两种成分被认为起源于单克隆前体。分子检测的证据支持单克隆理论，并表明外分泌成分可能产生内分泌成分，反之则不然。
病例报告
我们报告一例大肠腺瘤性息肉病例，该息肉有成群的内分泌细胞，起源于腺瘤性（外分泌）上皮的隐窝底部。据我们所知，我们的病例是第二例识别出微类癌内分泌细胞群的腺瘤性息肉报告。我们病例的组织学发现与混合性内分泌-外分泌肿瘤中描述的分子发现相关。
结论
我们的描述可能代表混合性内分泌-外分泌肿瘤的原始阶段。
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