Yilmaz Nafiye, Kahyaoglu İnci, İnal Hasan Ali, Görkem Ümit, Devran Aysun, Mollamahmutoglu Leyla
a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
b Department of Obstetrics and Gynecology , Etlik Zubeyde Hanım Women's Health Teaching and Research Hospital , Ankara , Turkey.
Hum Fertil (Camb). 2015 Sep;18(3):220-4. doi: 10.3109/14647273.2015.1022607. Epub 2015 Apr 1.
The aim of this study was to investigate the effect of negative life events on in-vitro-fertilization (IVF) outcome. Depression and negative life events were measured using Beck Depression Inventory (BDI) and List of Recent Events in 83 women attending the IVF clinic of a tertiary research and education hospital with the diagnosis of unexplained infertility between January 2013 and August 2013. Demographic features, stimulation parameters, depression scores, and negative life events of pregnant and non-pregnant participants were compared and the relation between negative life events, depression scores, and IVF outcome was investigated. Women who did not achieve a pregnancy experienced more negative life events than women who became pregnant (77.2% vs. 23.1%) (p > 0.001). The number of patients with moderate-to-severe depression (BDI scores > 16) was higher in the non-pregnant group than pregnant group (49.1% vs. 26.9%), however the difference was not statistically significant (p = 0.057). Clinical pregnancy showed a significant moderate negative correlation with the number of negative life events (r = -0.513, p = 0.001), but the correlation between clinical pregnancy and BDI scores was not statistically significant (r = -0.209, p = 0.059). Stressful life events have a negative influence on the quality of life, which eventually affects in IVF outcome, possibly through maladaptive lifestyle behavior.
本研究的目的是调查负面生活事件对体外受精（IVF）结局的影响。在2013年1月至2013年8月期间，对一家三级研究和教育医院的体外受精诊所中83名被诊断为不明原因不孕症的女性，使用贝克抑郁量表（BDI）和近期事件清单来测量抑郁和负面生活事件。比较了怀孕和未怀孕参与者的人口统计学特征、刺激参数、抑郁评分和负面生活事件，并研究了负面生活事件、抑郁评分与IVF结局之间的关系。未怀孕的女性比怀孕的女性经历了更多的负面生活事件（77.2%对23.1%）（p>0.001）。非怀孕组中中度至重度抑郁（BDI评分>16）的患者人数高于怀孕组（49.1%对26.9%），然而差异无统计学意义（p=0.057）。临床妊娠与负面生活事件的数量呈显著的中度负相关（r=-0.513，p=0.001），但临床妊娠与BDI评分之间的相关性无统计学意义（r=-0.209，p=0.059）。应激性生活事件会对生活质量产生负面影响，最终可能通过不良的生活方式行为影响IVF结局。
