Ratliff-Crain J, O'Keeffe M K, Baum A
Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.
Health Psychol. 1989;8(4):427-47. doi: 10.1037//0278-6133.8.4.427.
Forty habitual, heavy coffee drinkers (M = 5.7 cups/day) participated in two experimental sessions. Participants were deprived of their morning coffee for one of the laboratory sessions, not deprived the other. During each session, subjects consumed 12 oz of caffeinated coffee, decaffeinated coffee, or caffeine-free herbal tea. Measurements of heart rate, blood pressure, mood, and catecholamine response to deprivation and consumption of the beverage, alone and in combination with challenging tasks, were made. This study found that caffeine continues to cause blood pressure increases with chronic, heavy consumption and that these effects do not appear to habituate with regular use. Subjects reacted to behavioral challenge with fewer negative mood effects if they had consumed caffeine or coffee. Mild caffeine deprivation was associated with symptoms of stress.
四十名有喝咖啡习惯的重度咖啡饮用者（平均每天喝5.7杯）参加了两个实验环节。在其中一个实验环节中，参与者被剥夺了早晨的咖啡，另一个环节则没有。在每个环节中，受试者饮用12盎司含咖啡因的咖啡、脱咖啡因咖啡或无咖啡因的花草茶。研究人员测量了心率、血压、情绪以及单独饮用和与挑战性任务结合饮用饮料时，身体对剥夺和饮用饮料的儿茶酚胺反应。这项研究发现，长期大量饮用咖啡因会持续导致血压升高，而且这些影响似乎不会因经常饮用而习惯化。如果受试者饮用了咖啡因或咖啡，他们对行为挑战的负面情绪反应就会减少。轻度咖啡因剥夺与压力症状有关。
