Huh Dongeun Dan
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.
Ann Am Thorac Soc. 2015 Mar;12 Suppl 1(Suppl 1):S42-4. doi: 10.1513/AnnalsATS.201410-442MG.
Here we describe a microphysiological system that replicates the functional unit of the living human lung. This human "breathing lung-on-a-chip" microdevice provides unique capabilities to reconstitute three-dimensional microarchitecture, dynamic mechanical activity, and integrated physiological function of the alveolar-capillary interface. We demonstrate the potential of this microengineered biomimetic model for screening environmental particulates and modeling complex human disease processes.
在此,我们描述了一种复制人类活体肺功能单元的微生理系统。这种人类“芯片上的呼吸肺”微型装置具有独特的能力,可重建三维微结构、动态机械活动以及肺泡-毛细血管界面的综合生理功能。我们展示了这种微工程仿生模型在筛选环境颗粒物和模拟复杂人类疾病过程方面的潜力。