Caivano Rocchina, Villonio Antonio, D' Antuono Felice, Gioioso Matilde, Rabasco Paola, Iannelli Giancarlo, Zandolino Alexis, Lotumolo Antonella, Dinardo Giuseppina, Macarini Luca, Guglielmi Giuseppe, Cammarota Aldo
1IRCCS-CROB, Rionero in Vulture , Italy.
Cancer Invest. 2015 May;33(5):159-64. doi: 10.3109/07357907.2015.1019674. Epub 2015 Apr 1.
To evaluate the utility of diffusion-weighted-imaging (DWI) and apparent-diffusion-coefficient (ADC) in a 3T magnetic-resonance-imaging (MRI) study of breast cancer. In particular, the study aims to classify ADC-values according to histology either for benign or malignant lesions.
110 Breast MRI with MRI-DWI sequences and quantitative evaluation of the ADC were retrospectively reviewed. Results obtained with MRI-DWI and with biopsy were analyzed and ADC values were compared to histological results.
MRI showed a 95.5% sensitivity and a 83.7% specificity. The mean ADC values of benign and malignant lesions were 2.06 ± 0.19 and 1.03 ± 0.07 mm(2)/s, respectively (p < .05).
DWI and ADC-values could help distinguishing malignant and benign breast masses.
在一项关于乳腺癌的3T磁共振成像（MRI）研究中评估扩散加权成像（DWI）和表观扩散系数（ADC）的效用。具体而言，该研究旨在根据组织学对良性或恶性病变的ADC值进行分类。
回顾性分析110例采用MRI-DWI序列并对ADC进行定量评估的乳腺MRI检查。分析MRI-DWI及活检结果，并将ADC值与组织学结果进行比较。
MRI显示敏感性为95.5%，特异性为83.7%。良性和恶性病变的平均ADC值分别为2.06±0.19和1.03±0.07mm²/s（p<.05）。
DWI和ADC值有助于鉴别乳腺良恶性肿块。
