核糖核酸酶III操纵子通过mRNA加工进行的自动调节。
Autoregulation of RNase III operon by mRNA processing.
作者信息
Bardwell J C, Régnier P, Chen S M, Nakamura Y, Grunberg-Manago M, Court D L
机构信息
Laboratory of Chromosome Biology, Frederick Cancer Research Facility, MD 21701.
出版信息
EMBO J. 1989 Nov;8(11):3401-7. doi: 10.1002/j.1460-2075.1989.tb08504.x.
RNase III has been implicated in the control of gene expression by the processing of mRNA. We have found that the rnc operon is autoregulated; rnc- mutant strains oversynthesize the operon's mRNA and protein products. A site in the 5'-noncoding region of the operon's message is cleaved by RNase III. This site-specific cleavage appears to be the initial step in the functional inactivation of the message, since the half-life of the cut message is dramatically shorter than that of the uncut message.
核糖核酸酶III（RNase III）被认为通过加工信使核糖核酸（mRNA）来控制基因表达。我们发现核糖核酸酶III基因（rnc）操纵子是自我调节的；rnc突变菌株会过度合成该操纵子的mRNA和蛋白质产物。该操纵子信使核糖核酸5'-非编码区的一个位点被RNase III切割。这种位点特异性切割似乎是信使核糖核酸功能失活的起始步骤，因为被切割的信使核糖核酸的半衰期比未切割的信使核糖核酸的半衰期短得多。
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