Ata Muhammad Atif, Khand Fatehuddin, Shaikh Shumaila Shabbir, Ata Muhammad Adeel
J Pak Med Assoc. 2015 Jan;65(1):39-42.
To evaluate the effect of smoking on blood levels of xanthine oxidase and malondialdehyde in acute myocardial infarction patients.
The cross-sectional study was conducted from June to November 2013 and comprised myocardial infarction in-patients at Liaquat University of Medical and Health Sciences Hospital, Jamshoro, and Isra University Hospital, Hyderabad. Serum samples from age and gender matched smoking and non-smoking patients were investigated for the levels of xanthine oxidase and malondialdehyde by kit methods.
Of the 88 serum samples investigated, 68(77.3%) belonged to men and 20(22.7%) to women. Among the 44 smokers, 35(79.5%) were men and 9(20.5%) were women.The overall mean age of the group was 49.6±8.0 years. Among the 44 non-smokers, 33(75%) were men and 11(25%) women. The overall mean age of the group was 50.9±8.4 Years. Smokers compared to non-smokers had significantly raised mean serum xanthine oxidase (0.31±0.05 vs 0.28±0.03mg/dl; p<0.05) and malondialdehyde (32.29±3.30 vs 30.30±2.87 µmol/L; p<0.04) levels.
Smokers as against the non-smokers were at higher risk of developing acute myocardial infarction owing to increased level of oxidative stress caused by smoking.
评估吸烟对急性心肌梗死患者血液中黄嘌呤氧化酶和丙二醛水平的影响。
本横断面研究于2013年6月至11月进行，纳入了位于贾姆肖罗的利亚卡特医科与健康科学大学医院以及海得拉巴的伊斯雷尔大学医院的心肌梗死住院患者。采用试剂盒方法对年龄和性别匹配的吸烟和非吸烟患者的血清样本进行黄嘌呤氧化酶和丙二醛水平检测。
在检测的88份血清样本中，68份（77.3%）来自男性，20份（22.7%）来自女性。在44名吸烟者中，35名（79.5%）为男性，9名（20.5%）为女性。该组总体平均年龄为49.6±8.0岁。在44名非吸烟者中，33名（75%）为男性，11名（25%）为女性。该组总体平均年龄为50.9±8.4岁。与非吸烟者相比，吸烟者的平均血清黄嘌呤氧化酶水平（0.31±0.05 vs 0.28±0.03mg/dl；p<0.05）和丙二醛水平（32.29±3.30 vs 30.30±2.87µmol/L；p<0.04）显著升高。
与非吸烟者相比，吸烟者因吸烟导致氧化应激水平升高，发生急性心肌梗死的风险更高。
