Budai D, Vu H Q, Duckles S P
Department of Pharmacology, College of Medicine, University of California, Irvine 92717.
Eur J Pharmacol. 1989 Sep 1;168(1):97-100. doi: 10.1016/0014-2999(89)90638-9.
Influence of endothelial cells on the effect of neuropeptide Y (NPY) was investigated. NPY (30 nM) doubled the vasoconstriction elicited by transmural nerve stimulation (8 pulses at 8 Hz) in the perfused rabbit ear artery with or without endothelium. Conditions that increase the biophase concentration of norepinephrine, longer stimulation trains or application of yohimbine, decreased the potentiation by NPY, although in the presence of cocaine potentiation by NPY was unchanged. However, no significant differences between control and endothelium-removed arteries were revealed. Thus modulation of adrenergic neurotransmission by NPY does not depend on endothelium-derived vasoactive substances.
研究了内皮细胞对神经肽Y（NPY）作用的影响。在有或无内皮的灌注兔耳动脉中，NPY（30 nM）使经壁神经刺激（8 Hz下8个脉冲）引起的血管收缩增加了一倍。增加去甲肾上腺素生物相浓度的条件，如更长的刺激序列或应用育亨宾，会降低NPY的增强作用，尽管在存在可卡因的情况下，NPY的增强作用不变。然而，对照组和去除内皮的动脉之间未发现显著差异。因此，NPY对肾上腺素能神经传递的调节不依赖于内皮衍生的血管活性物质。
