兔耳动脉中诱发的去甲肾上腺素释放：嘌呤增强、神经肽Y减弱以及降钙素基因相关肽无作用
Evoked noradrenaline release in the rabbit ear artery: enhancement by purines, attenuation by neuropeptide Y and lack of effect of calcitonin gene-related peptide.
作者信息
Maynard K I, Burnstock G
机构信息
Department of Anatomy and Developmental Biology, University College London.
出版信息
Br J Pharmacol. 1994 May;112(1):123-6. doi: 10.1111/j.1476-5381.1994.tb13040.x.
Abstract
- Adenosine (30 microM) and its analogues 5'-N-ethylcarboxaminoadenosine (5 and 30 microM) and L-phenylisopropyladenosine (5 and 30 microM), potentiated the evoked but not spontaneous release of tritiated noradrenaline in the rabbit central ear artery. 2. Prejunctional inhibition of the evoked but not spontaneous release of tritiated noradrenaline by 100 nM neuropeptide Y is greater at 2 min than at 10 min after superfusion of the peptide. 3. Calcitonin gene-related peptide (2.63 to 263 nM) did not affect the evoked or spontaneous release of tritiated noradrenaline in this preparation. 4. These results are discussed in terms of prejunctional modulation of sympathetic transmission in the rabbit central ear artery.
摘要
- 腺苷（30微摩尔）及其类似物5'-N-乙基羧氨基腺苷（5微摩尔和30微摩尔）和L-苯异丙基腺苷（5微摩尔和30微摩尔），增强了兔中耳动脉中诱发的而非自发的氚化去甲肾上腺素释放。2. 100纳摩尔神经肽Y对诱发的而非自发的氚化去甲肾上腺素释放的接头前抑制在灌注该肽后2分钟比10分钟时更强。3. 降钙素基因相关肽（2.63至263纳摩尔）在此制剂中不影响诱发的或自发的氚化去甲肾上腺素释放。4. 根据兔中耳动脉交感神经传递的接头前调节对这些结果进行了讨论。
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本文引用的文献
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