[D2多巴胺受体基因-141C插入/缺失多态性与中国汉族人群海洛因依赖的关联：一项荟萃分析]

[Association of D2 dopamine receptor gene -141C Ins/Del polymorphisms with heroin dependence in Chinese Han population: a meta-analysis].

作者信息

Hu Peiwu, Li Xingli, Peng Shasha, Luo Xi, Liu Zhisheng

机构信息

Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 Mar;40(3):233-40. doi: 10.11817/j.issn.1672-7347.2015.03.001.

DOI:10.11817/j.issn.1672-7347.2015.03.001

PMID:25832525

Abstract

OBJECTIVE

To evaluate the association between D2 dopamine receptor gene -141C Ins/Del polymorphism and heroin dependence in Chinese Han population.

METHODS

Chinese and foreign databases were searched for relevant articles published from the establishment of database to March 2014. Case-control studies on D2 dopamine receptor gene -141C Ins/Del polymorphism with heroin dependence in Chinese Han population were gathered with Meta-analysis by Stata 12.0 software after data abstraction.

RESULTS

Seven case-control studies on association between D2 dopamine receptor gene -141C Ins/ Del polymorphism and heroin dependence were included, which covered 3 211 heroin dependence patients and 1 979 controls. Meta-analysis results showed that the pooled odds ratio (OR), the 95% confidence interval (CI) and P value after combining genotypes were as follows: Ins/Ins vs Del/Del: OR=0.51, 95% CI: 0.27-0.96, P=0.017; Ins/Ins vs Ins/Del+Del/Del: OR=0.82, 95% CI: 0.72-0.94, P=0.448; Ins/Ins+ Ins/Del vs Del/Del: OR=0.53, 95% CI: 0.28-0.98, P=0.019; Ins/Del vs Del/Del: OR=0.59, 95% CI: 0.32-1.07, P=0.045; Ins vs Del: OR=0.79, 95% CI: 0.71-0.89, P=0.101).

CONCLUSION

D2 dopamine receptor gene -141C Ins/Del polymorphism is associated with heroin dependence in Chinese Han population, and Chinese Han population with Ins allele gene deletion are at lower risk of heroin dependence.

摘要

目的

评估D2多巴胺受体基因-141C Ins/Del多态性与中国汉族人群海洛因依赖之间的关联。

方法

检索中外数据库中从数据库建立至2014年3月发表的相关文章。提取数据后，采用Stata 12.0软件对中国汉族人群中D2多巴胺受体基因-141C Ins/Del多态性与海洛因依赖的病例对照研究进行Meta分析。

结果

纳入7项关于D2多巴胺受体基因-141C Ins/Del多态性与海洛因依赖关联的病例对照研究，共涵盖3211例海洛因依赖患者和1979例对照。Meta分析结果显示，合并基因型后的合并比值比（OR）、95%置信区间（CI）及P值如下：Ins/Ins与Del/Del比较：OR = 0.51，95% CI：0.27 - 0.96，P = 0.017；Ins/Ins与Ins/Del + Del/Del比较：OR = 0.82，95% CI：0.72 - 0.94，P = 0.448；Ins/Ins + Ins/Del与Del/Del比较：OR = 0.53，95% CI：0.28 - 0.98，P = 0.019；Ins/Del与Del/Del比较：OR = 0.59，95% CI：0.32 - 1.07，P = 0.045；Ins与Del比较：OR = 0.79，95% CI：0.71 - 0.89，P = 0.101）。