Wang Yurong, Liu Li, Xin Lihong, Fan Dazhi, Ding Ning, Hu Yanting, Cai Guoqi, Wang Li, Xia Qing, Li Xiaona, Yang Xiao, Zou Yanfeng, Pan Faming
Medical Department of Hefei Vocational and Technical College, Hefei, Anhui, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
J Clin Neurosci. 2016 Aug;30:1-7. doi: 10.1016/j.jocn.2015.10.052. Epub 2016 Jun 6.
It has been reported that two single nucleotide polymorphisms (SNP) Taq1A and -141C Ins/Del in the DRD2 gene may be associated with susceptibility to schizophrenia. Due to inconclusive and mixed results, a meta-analysis was conducted to further clarify the relationship between the two SNP and schizophrenia susceptibility. A systematic literature search for the association of these two SNP with schizophrenia susceptibility was conducted using PubMed, ScienceDirect, Chinese Biomedical Literature Database, and Chinese National Knowledge Infrastructure. Odds ratios (OR) with 95% confidence intervals (CI) were used to assess the strength of the associations reported. A total of 5558 schizophrenic patients and 6792 healthy controls from 31 articles were included in this study. Evidence regarding the association between -141C Ins/Del polymorphism and schizophrenia was found in the allele frequency comparison (Ins versus Del: OR 1.29, 95% CI 1.06-1.57; p=0.01, Praw=0.1, PFalse Discovery Rate=0.023). In ethnic subgroup analysis, the result revealed that the 141C Ins/Del polymorphism was associated with schizophrenia in all genetic models in Asians, but not in Caucasians. For Taq1A polymorphism, a significant association was found in the allele frequency (A1 versus A2: OR 0.71, 95% CI 0.52-0.98, p=0.03). Stratification by ethnicity indicated an association between the Taq1A polymorphism and schizophrenia in Asians, but not Caucasians. The present study suggests that the -141C Ins/Del polymorphism carries a significantly increased risk of schizophrenia, while the Taq1A polymorphism carries a significantly decreased risk of schizophrenia susceptibility in Asians.
据报道，DRD2基因中的两个单核苷酸多态性（SNP）Taq1A和-141C Ins/Del可能与精神分裂症易感性相关。由于结果不确定且相互矛盾，因此进行了一项荟萃分析以进一步阐明这两个SNP与精神分裂症易感性之间的关系。使用PubMed、ScienceDirect、中国生物医学文献数据库和中国知网对这两个SNP与精神分裂症易感性的关联进行了系统的文献检索。采用优势比（OR）及95%置信区间（CI）来评估所报道关联的强度。本研究纳入了来自31篇文章的5558例精神分裂症患者和6792例健康对照。在等位基因频率比较中发现了-141C Ins/Del多态性与精神分裂症之间关联的证据（Ins与Del比较：OR 1.29，95%CI 1.06-1.57；p=0.01，Praw=0.1，P错误发现率=0.023）。在种族亚组分析中，结果显示141C Ins/Del多态性在亚洲人的所有遗传模型中均与精神分裂症相关，而在白种人中则不然。对于Taq1A多态性，在等位基因频率中发现了显著关联（A1与A2比较：OR 0.71，95%CI 0.52-0.98，p=0.03）。按种族分层表明Taq1A多态性与亚洲人的精神分裂症相关，但与白种人无关。本研究表明，-141C Ins/Del多态性使精神分裂症风险显著增加，而Taq1A多态性使亚洲人精神分裂症易感性风险显著降低。
