Chi Yung-Wei, Raffetto Joseph D
Department of Internal Medicine, Section of Cardiovascular Medicine, University of California, Davis Medical Center, Sacramento, CA, USA
Vascular Surgery Division, VA Boston Healthcare System, West Roxbury, MA, USA Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA.
Vasc Med. 2015 Apr;20(2):168-81. doi: 10.1177/1358863X14568677.
Venous leg ulceration (VLU) is one of the most predominate medical disorders worldwide and in the western hemisphere it affects around 1.5% of the general population and up to 5% of the elderly population. Unfortunately, this trend will only increase given the growth of an aging population worldwide. Understanding its pathophysiology that begins with venous hemodynamic abnormalities and leads to inflammatory alterations with microcirculatory changes is critical to delivering effective curative therapy. As such, the main component to treatment is reversing the underlying venous hypertension and pro-inflammatory milieu using compression treatment along with various adjuvant therapies. Given its impact, a comprehensive multi-pronged approach to care, treatment and prevention is required to reverse the increasing trend that is observed worldwide.
下肢静脉溃疡（VLU）是全球最主要的医学病症之一，在西半球，它影响着约1.5%的普通人群，在老年人群中这一比例高达5%。不幸的是，鉴于全球老龄化人口的增长，这种趋势只会加剧。了解其始于静脉血液动力学异常并导致伴有微循环变化的炎症改变的病理生理学，对于提供有效的治疗至关重要。因此，治疗的主要组成部分是使用压迫治疗以及各种辅助疗法来逆转潜在的静脉高压和促炎环境。鉴于其影响，需要采取全面的多管齐下的护理、治疗和预防方法，以扭转全球范围内观察到的上升趋势。
