异基因造血细胞移植前儿童体内的BK病毒抗体。
Antibodies to BK virus in children prior to allogeneic hematopoietic cell transplant.
作者信息
Laskin Benjamin L, Sullivan Kathleen E, Hester Jeff, Goebel Jens, Davies Stella M, Jodele Sonata
机构信息
Division of Nephrology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
出版信息
Pediatr Blood Cancer. 2015 Sep;62(9):1670-3. doi: 10.1002/pbc.25536. Epub 2015 Apr 1.
Abstract
BK virus (BKV) is associated with kidney and bladder disease after hematopoietic cell transplantation (HCT) but less is known about the seroprevalence of pre-transplant antibodies to BKV in children. We measured BKV IgG antibody titers in 36 children before HCT. BKV IgG antibodies were detected in all 36 patients, with 28/36 (77.8%) developing BK viremia in the first 100 days. Pre-HCT BKV IgG antibody titers >1:40,960 were protective against later BK viremia ≥10,000 copies/ml. The seroprevalence of antibodies to BKV is high in children undergoing HCT and post-transplant BK viremia, which is associated with bladder and kidney injury, is common.
摘要
BK病毒（BKV）与造血细胞移植（HCT）后的肾脏和膀胱疾病有关，但对于儿童移植前抗BKV抗体的血清流行率了解较少。我们检测了36名儿童在HCT前的BKV IgG抗体滴度。所有36例患者均检测到BKV IgG抗体，其中28/36（77.8%）在最初100天内发生BK病毒血症。移植前BKV IgG抗体滴度>1:40,960可预防后期BK病毒血症≥10,000拷贝/毫升。接受HCT的儿童中抗BKV抗体的血清流行率很高，且与膀胱和肾脏损伤相关的移植后BK病毒血症很常见。
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