Lin Cheng-Jui, Lin Jackson, Pan Chi-Feng, Chuang Chih-Kuang, Liu Hsuan-Liang, Sun Fang-Ju, Wang Tuan-Jen, Chen Han-Hsiang, Wu Chih-Jen
Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei and Hsin-Chu, Taiwan.
Kidney Blood Press Res. 2015;40(2):121-9. doi: 10.1159/000368488. Epub 2015 Mar 19.
BACKGROUND/AIMS: Advanced glycation end products (AGEs) are pro-inflammatory and pro-oxidative compounds that play a critical role in endothelial dysfunction and atherosclerosis. Protein-bound uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate (PCS), inhibit endothelial function. We explored the association of IS and PCS with AGEs in a hemodialysis (HD) cohort.
This study was a cross-sectional study that recruited 129 stable patients on maintenance HD in a single medical center from July 1 to July 15, 2011. Serum levels of total and free IS, PCS and AGEs were measured concurrently. General laboratory results and patient background were also investigated.
Serum levels of AGEs were associated with total IS (r = 2.7, p < 0.01) but not total PCS (r = 0.01, NS), free IS (r = 0.11, NS) or free PCS (r = 0.04, NS) using Pearson's analysis. Multiple linear regression analysis showed that total IS was significantly related to AGEs (β = 0.296, p < 0.01), free IS (β = 0.502, p < 0.01) and creatinine (β = 0.294, p < 0.01). Serum AGEs levels were also independently correlated with diabetes status (β = 0.250, p = 0.01) and total IS (β = 0.341, p < 0.01) concentrations after adjusting for other confounding variables. Moreover, patients with diabetes had higher serum AGEs levels than patients without diabetes (p < 0.01).
These findings suggest that serum levels of total IS were associated with AGEs levels, which may participate in the process of atherosclerosis.
背景/目的：晚期糖基化终产物（AGEs）是促炎和促氧化化合物，在血管内皮功能障碍和动脉粥样硬化中起关键作用。蛋白结合型尿毒症毒素，硫酸吲哚酚（IS）和对甲酚硫酸盐（PCS），会抑制内皮功能。我们在一个血液透析（HD）队列中探究了IS和PCS与AGEs之间的关联。
本研究为横断面研究，于2011年7月1日至7月15日在单个医疗中心招募了129例维持性HD稳定患者。同时测量血清中总IS、游离IS、PCS和AGEs的水平。还调查了一般实验室检查结果和患者背景情况。
使用Pearson分析，血清AGEs水平与总IS相关（r = 2.7，p < 0.01），但与总PCS（r = 0.01，无显著性差异）、游离IS（r = 0.11，无显著性差异）或游离PCS（r = 0.04，无显著性差异）无关。多元线性回归分析显示，总IS与AGEs显著相关（β = 0.296，p < 0.01）、游离IS（β = 0.502，p < 0.01）和肌酐（β = 0.294，p < 0.01）。在调整其他混杂变量后，血清AGEs水平也与糖尿病状态（β = 0.250，p = 0.01）和总IS浓度（β = 0.341，p < 0.01）独立相关。此外，糖尿病患者的血清AGEs水平高于非糖尿病患者（p < 0.01）。
这些发现表明，血清总IS水平与AGEs水平相关，这可能参与了动脉粥样硬化的进程。
