Pison Laurent, Potpara Tatjana S, Chen Jian, Larsen Torben B, Bongiorni Maria Grazia, Blomström-Lundqvist Carina
Department of Cardiology, Maastricht University Medical Centre and Cardiovascular Research Institute, PO Box 5800, Maastricht 6229 HX, The Netherlands
School of Medicine, University of Belgrade, Serbia and Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia.
Europace. 2015 Apr;17(4):642-6. doi: 10.1093/europace/euv069.
The purpose of this EP Wire was to assess the indications, techniques, and outcomes of left atrial appendage occlusion (LAAO) in Europe. Thirty-three European centres, all members of the European Heart Rhythm Association electrophysiology (EP) research network, responded to this survey by completing the questionnaire. The major indication for LAAO (94%) was the prevention of stroke in patients at high thrombo-embolic risk (CHA2DS2-VASc ≥ 2) and contraindications to oral anticoagulants (OACs). Twenty-one (64%) of the responding centres perform LAAO in their own institution and 80% implanted 30 or less LAAO devices in 2014. Two-dimensional transoesophageal echocardiography was the preferred imaging technique to visualize LAA before, during, and after LAAO in 79, 58, and 62% of the participating centres, respectively. Following LAAO, 49% of the centres prescribe vitamin K antagonists or novel OACs. Twenty-five per cent of the centres combine LAAO with pulmonary vein isolation. The periprocedural complications included death (range, 0-3%), ischaemic or haemorrhagic stroke (0-25%), tamponade (0-25%), and device embolization (0-20%). In conclusion, this EP Wire has demonstrated that LAAO is most commonly employed in patients at high thrombo-embolic risk in whom OAC is contraindicated. The technique is not yet very widespread and the complication rates remain significant.
本欧洲心律协会(EHRA)电生理(EP)研究报告旨在评估欧洲左心耳封堵术(LAAO)的适应症、技术及疗效。欧洲心律协会电生理研究网络的33个欧洲中心通过填写问卷对此次调查做出了回应。LAAO的主要适应症(94%)是预防高血栓栓塞风险(CHA2DS2-VASc≥2)且口服抗凝剂(OAC)存在禁忌的患者发生中风。21个(64%)做出回应的中心在其机构内开展LAAO,80%的中心在2014年植入了30个或更少的LAAO装置。在参与调查的中心中,分别有79%、58%和62%在LAAO术前、术中和术后选择二维经食管超声心动图作为观察左心耳的首选成像技术。LAAO术后,49%的中心会开具维生素K拮抗剂或新型OAC。25%的中心将LAAO与肺静脉隔离相结合。围手术期并发症包括死亡(范围为0 - 3%)、缺血性或出血性中风(0 - 25%)、心包填塞(0 - 25%)和装置栓塞(0 - 20%)。总之,本欧洲心律协会研究报告表明,LAAO最常用于OAC存在禁忌的高血栓栓塞风险患者。该技术尚未广泛应用,并发症发生率仍然较高。