Brechmann Thorsten, Swol Justyna, Knop-Hammad Veronika, Willert Jörg, Aach Mirko, Cruciger Oliver, Schmiegel Wolff, Schildhauer Thomas A, Hamsen Uwe
Thorsten Brechmann, Wolff Schmiegel, Jörg Willert, Department of Gastroenterology and Hepatology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Ruhr-University Bochum, 44789 Bochum, Germany.
World J Gastroenterol. 2015 Mar 28;21(12):3736-40. doi: 10.3748/wjg.v21.i12.3736.
A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile (C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up.
一名65岁男性因急性脊髓损伤导致不完全性四肢瘫痪，在因肺炎接受抗生素治疗后出现严重复发性艰难梭菌感染。在经历了包括甲硝唑、万古霉素、非达霉素、利福昔明和替加环素在内的抗菌治疗无效且导致多次复发的病史后，该患者接受了来自其健康儿子的结肠镜下粪便微生物群移植。移植术后四天，患者出现全身炎症反应综合征。在未检测到感染原因的情况下，患者接受了抗菌治疗，包括替加环素、甲硝唑、通过聚乙二醇给予的万古霉素以及额外的灌肠治疗，为期七天，从而迅速康复，并且在12周的随访期间未报告艰难梭菌感染复发。
