Gravito-Soares Marta, Gravito-Soares Elisa, Portela Francisco, Ferreira Manuela, Sofia Carlos
Gastroenterology Department, Coimbra University Hospital, Portugal.
Gastroenterology Department, Coimbra University Hospital.
Rev Esp Enferm Dig. 2017 Jun;109(6):473-476. doi: 10.17235/reed.2017.4819/2016.
The use of fecal microbiota transplantation in recurrent Clostridium difficile infection and coexistent inflammatory bowel disease remains unclear. A 61-year-old man with ulcerative pancolitis was diagnosed with a third recurrence of Clostridium difficile infection, previously treated with metronidazole, vancomycin and fidaxomicin. Fecal microbiota transplantation of an unrelated healthy donor was performed by the lower route. After a twelve month follow-up, the patient remains asymptomatic without Clostridium difficile infection relapses or inflammatory bowel disease flare-ups. Fecal microbiota transplantation is relatively simple to perform, well-tolerated, safe and effective in recurrent Clostridium difficile infection with ulcerative pancolitis, as an alternative in case of antibiotic therapy failure.
粪便微生物群移植在复发性艰难梭菌感染和并存的炎症性肠病中的应用仍不明确。一名61岁的溃疡性全结肠炎男性被诊断为艰难梭菌感染第三次复发，此前曾接受甲硝唑、万古霉素和非达霉素治疗。通过低位途径进行了来自无关健康供体的粪便微生物群移植。经过12个月的随访，患者无症状，未出现艰难梭菌感染复发或炎症性肠病发作。粪便微生物群移植操作相对简单，耐受性良好，在伴有溃疡性全结肠炎的复发性艰难梭菌感染中安全有效，可作为抗生素治疗失败时的一种替代方法。
