患有II型糖尿病的沙特绝经后肥胖女性的骨转换生物标志物

Bone turnover biomarkers in obese postmenopausal Saudi women with type-II diabetes mellitus.

作者信息

Alselami Nada M, Noureldeen Amani F H, Al-Ghamdi Maryam A, Khan Jalaluddin A, Moselhy Said S

机构信息

Biochemistry department, Faculty of science, King Abdulaziz University, Jeddah, KSA.

Biochemistry department, Faculty of science, King Abdulaziz University, Jeddah, KSA ; Biochemistry department, Faculty of science, Ain Shams University, Cairo, Egypt.

出版信息

Afr Health Sci. 2015 Mar;15(1):90-6. doi: 10.4314/ahs.v15i1.12.

DOI:10.4314/ahs.v15i1.12

PMID:25834535

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4370142/

Abstract

BACKGROUND

There is a high prevalence of diabetes mellitus type-2 (T2DM) and osteoporosis are problems worldwide. In this study, we evaluated the correlation between T2DM and bone turnover in diabetic obese postmenopausal Saudi women.

SUBJECTS AND METHODS

The present study included total of 65 T2-DM obese postmenopausal Saudi women, (36 uncontrolled, 29 controlled). The following serum biochemical parameters were evaluated [fasting blood glucose (FBG), total calcium (Ca), phosphorus (Pi), parathyroid hormone (PTH), 1,25-(OH)2 Vitamin D3, osteocalcin (OC), procollagen (PICP) and cathepsin k (Cath K)].

RESULTS

Serum OC levels were significantly decreased in diabetic obese postmenopausal group compared to their respective healthy group (P < 0.004). PICP and Cath K were significantly elevated in diabetic postmenopausal group compared to the healthy group (P < 0.024 & 0.001). A significant elevation in 1,25(OH)2 Vitamin D3, Ca and Pi levels in diabetic obese postmenopausal patients group compared to the healthy group. However, a non-significant changes was observed in serum PTH level between different groups.

CONCLUSION

In this study, the changes in the biochemical parameters and bone turnover markers in obese women are strong risk factors for diabetes development that may contribute to osteopenia and osteoporosis. The study showed the strong effect of T2DM on biochemical markers of bone turnover in obese postmenopausal Saudi women.

摘要

背景

2型糖尿病（T2DM）和骨质疏松症在全球范围内都是普遍存在的问题。在本研究中，我们评估了沙特绝经后肥胖糖尿病女性中T2DM与骨转换之间的相关性。

研究对象与方法

本研究共纳入65名沙特绝经后肥胖T2-DM女性（36名未控制组，29名控制组）。评估了以下血清生化参数[空腹血糖（FBG）、总钙（Ca）、磷（Pi）、甲状旁腺激素（PTH）、1,25-（OH）2维生素D3、骨钙素（OC）、前胶原（PICP）和组织蛋白酶k（Cath K）]。

结果

与各自的健康组相比，糖尿病肥胖绝经后组的血清OC水平显著降低（P < 0.004）。与健康组相比，糖尿病绝经后组的PICP和Cath K显著升高（P < 0.024和0.001）。与健康组相比，糖尿病肥胖绝经后患者组的1,25（OH）2维生素D3、Ca和Pi水平显著升高。然而，不同组之间血清PTH水平的变化无统计学意义。