Laboratory of Experimental Medicine and Endocrinology, University Hospital Gasthuisberg, Catholic University of Leuven, B-3000 Leuven, Belgium.
Mol Cell Endocrinol. 2011 Dec 5;347(1-2):106-20. doi: 10.1016/j.mce.2011.08.016. Epub 2011 Aug 26.
Experimental evidence indicates that vitamin D may play a role in the defense against type 1 diabetes (T1D) as well as type 2 diabetes (T2D). Epidemiological data have established a link between vitamin D deficiency and an increased incidence of both T1D and T2D, whereas early and long-term vitamin D supplementation may decrease the risk of these disorders. The protective effects of vitamin D are mediated through the regulation of several components such as the immune system and calcium homeostasis. However, an increasing amount of evidence suggests that vitamin D also affects beta cells directly thereby rendering them more resistant to the types of cellular stress encountered during T1D and T2D. This review evaluates the role of vitamin D signaling in the pathogenesis of T1D and T2D with a special emphasis on the direct effects of vitamin D on pancreatic beta cells.
实验证据表明，维生素 D 可能在抵抗 1 型糖尿病 (T1D) 和 2 型糖尿病 (T2D) 方面发挥作用。 流行病学数据已经确定了维生素 D 缺乏症与 T1D 和 T2D 发病率增加之间的联系，而早期和长期补充维生素 D 可能会降低这些疾病的风险。 维生素 D 的保护作用是通过调节免疫系统和钙稳态等几个成分来介导的。 然而，越来越多的证据表明，维生素 D 也直接影响β细胞，从而使它们对 T1D 和 T2D 期间遇到的细胞应激更具抵抗力。 本综述评估了维生素 D 信号在 T1D 和 T2D 发病机制中的作用，特别强调了维生素 D 对胰腺β细胞的直接作用。
