综述：α-突触核蛋白与认知的关联。
Mini review: linkage between α-Synuclein protein and cognition.
机构信息
Center for Advanced Therapeutic Strategies for Brain Disorders Roskamp Institute, Sarasota, FL 34243 USA.
Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243 USA.
出版信息
Transl Neurodegener. 2015 Mar 28;4:5. doi: 10.1186/s40035-015-0026-0. eCollection 2015.
α-synuclein is a protein that plays important roles in cognitive function in the normal brain, although its exact role is not fully understood. However, current studies reveal that defects in α-synuclein function could contribute to various neurodegenerative disorders, such as Parkinson's disease (PD), a disease with symptomatic progression of deterioration in motor and cognitive function. Recent studies show that the level of α -synuclein in cerebrospinal fluid (CSF) is highly correlated with speed of cognitive decline, suggesting a potential role of α-synuclein in cognitive function. In this mini review, we will be focus on literatures of α-synuclein in cognitive function in the non-diseased brain, as well as the impact that defective α-synuclein has on cognition in disease brain. This will be accomplished by assessing the effects of soluble α-synuclein, α-synuclein oligomers, and extracellular α-synuclein transport, on neurodegeneration.
α- 突触核蛋白是一种在正常大脑的认知功能中发挥重要作用的蛋白质，尽管其确切作用尚不完全清楚。然而，目前的研究表明，α- 突触核蛋白功能的缺陷可能导致各种神经退行性疾病，如帕金森病 (PD)，这是一种以运动和认知功能恶化的症状进展为特征的疾病。最近的研究表明，脑脊液 (CSF) 中的 α - 突触核蛋白水平与认知衰退的速度高度相关，这表明 α- 突触核蛋白在认知功能中可能发挥作用。在这篇迷你综述中，我们将重点关注非病变大脑中 α- 突触核蛋白在认知功能中的文献，以及缺陷的 α- 突触核蛋白对疾病大脑认知的影响。这将通过评估可溶性 α- 突触核蛋白、α- 突触核蛋白寡聚物和细胞外 α- 突触核蛋白转运对神经退行性变的影响来实现。
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