Sheybani Fereshte, Naderi HamidReza, Sarvghad MohammadReza, Ghabouli MohammadJavad, Arian Mahnaz
Department of infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Imam Reza Teaching Hospital, Mashhad 9137913316, Iran.
Med Mycol Case Rep. 2015 Mar 11;8:29-31. doi: 10.1016/j.mmcr.2015.03.003. eCollection 2015 Jun.
This report presents two cases of invasive rhino-orbital mucormycosis who had life-threatening reactions to amphotericin B. Both cases were treated with a combination of posaconazole-caspofungin favorably with no evidence of recurrence upon long-term follow-up. To our knowledge, this is the first report of successful treatment of invasive mucormycosis with azole-echinocandin combination. It may suggest that caspofungin exerts additional or even synergistic antimucoral effects to posaconazole.
本报告介绍了两例侵袭性鼻眶毛霉菌病患者，他们对两性霉素B产生了危及生命的反应。两例患者均接受泊沙康唑-卡泊芬净联合治疗，效果良好，长期随访无复发迹象。据我们所知，这是首例使用唑类-棘白菌素联合成功治疗侵袭性毛霉菌病的报告。这可能表明卡泊芬净对泊沙康唑具有额外甚至协同的抗霉菌作用。
