对于患有侵袭性毛霉病且对两性霉素B发生危及生命反应的患者，我们应如何进行治疗？两例报告及文献综述。
How should we manage a patient with invasive mucoromycosis who develops life-threatening reaction to amphotericin B? Report of two cases and literature review.
作者信息
Sheybani Fereshte, Naderi HamidReza, Sarvghad MohammadReza, Ghabouli MohammadJavad, Arian Mahnaz
机构信息
Department of infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Imam Reza Teaching Hospital, Mashhad 9137913316, Iran.
出版信息
Med Mycol Case Rep. 2015 Mar 11;8:29-31. doi: 10.1016/j.mmcr.2015.03.003. eCollection 2015 Jun.
Abstract
This report presents two cases of invasive rhino-orbital mucormycosis who had life-threatening reactions to amphotericin B. Both cases were treated with a combination of posaconazole-caspofungin favorably with no evidence of recurrence upon long-term follow-up. To our knowledge, this is the first report of successful treatment of invasive mucormycosis with azole-echinocandin combination. It may suggest that caspofungin exerts additional or even synergistic antimucoral effects to posaconazole.
摘要
本报告介绍了两例侵袭性鼻眶毛霉菌病患者，他们对两性霉素B产生了危及生命的反应。两例患者均接受泊沙康唑-卡泊芬净联合治疗，效果良好，长期随访无复发迹象。据我们所知，这是首例使用唑类-棘白菌素联合成功治疗侵袭性毛霉菌病的报告。这可能表明卡泊芬净对泊沙康唑具有额外甚至协同的抗霉菌作用。
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Combination therapy for mucormycosis: why, what, and how?联合治疗毛霉病：为什么、用什么、怎么用？
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Lessons from a case of oromandibular mucormycosis treated with surgery and a combination of amphotericin B lipid formulation plus caspofungin.口腔颌面部毛霉菌病治疗手术联合两性霉素 B 脂质体加卡泊芬净的病例分析
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