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两性霉素B与卡泊芬净联合治疗毛霉病

Combination of amphotericin B and caspofungin in the treatment of mucormycosis.

作者信息

Gargouri Marwa, Marrakchi Chakib, Feki Wiem, Charfi Slim, Maaloul Imed, Lahiani Dorra, Elleuch Emna, Koubaa Makram, Mnif Zineb, Ayadi Ali, Boudawara Tahiya, Ben Jemaa Mounir

机构信息

Department of Infectious Diseases, Hedi Chaker University Hospital, Sfax, Tunisia.

Department of Radiology, Hedi Chaker University Hospital, Sfax, Tunisia.

出版信息

Med Mycol Case Rep. 2019 Sep 21;26:32-37. doi: 10.1016/j.mmcr.2019.09.006. eCollection 2019 Dec.

DOI:10.1016/j.mmcr.2019.09.006
PMID:31667058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6812035/
Abstract

We report a case of invasive mucormycosis in 52 year-old woman. CT-scan and magnetic resonance imaging found a partial right sinus thrombosis associated with homolateral ethmoidal and maxillary sinusitis with submucosal inflammation. Histopathological examination of excised tissue was positive for mucormycosis. Our patient was treated by surgical debridement and a combination of amphotericin B and caspofungin, with a good outcome.

摘要

我们报告一例52岁女性侵袭性毛霉病病例。CT扫描和磁共振成像发现右侧部分鼻窦血栓形成，伴有同侧筛窦和上颌窦炎及黏膜下炎症。切除组织的组织病理学检查显示毛霉病阳性。我们的患者接受了手术清创以及两性霉素B和卡泊芬净联合治疗，效果良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921a/6812035/73a85561f9e8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921a/6812035/e850d24679cd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921a/6812035/7519b2633a39/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921a/6812035/8f23176905b6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921a/6812035/0b54e7680ed7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921a/6812035/73a85561f9e8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921a/6812035/e850d24679cd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921a/6812035/7519b2633a39/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921a/6812035/8f23176905b6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921a/6812035/0b54e7680ed7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921a/6812035/73a85561f9e8/gr6.jpg

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Med Mycol Case Rep. 2015 Mar 11;8:29-31. doi: 10.1016/j.mmcr.2015.03.003. eCollection 2015 Jun.
2
Stability in the cumulative incidence, severity and mortality of 101 cases of invasive mucormycosis in high-risk patients from 1995 to 2011: a comparison of eras immediately before and after the availability of voriconazole and echinocandin-amphotericin combination therapies.1995年至2011年101例高危患者侵袭性毛霉病的累积发病率、严重程度和死亡率的稳定性：伏立康唑和棘白菌素-两性霉素联合疗法可用前后时代的比较
Mycoses. 2014 Nov;57(11):687-98. doi: 10.1111/myc.12222. Epub 2014 Jul 18.
3
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Curr Med Mycol. 2022 Mar;8(1):26-31. doi: 10.18502/cmm.8.1.9211.
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Current Treatment Options for COVID-19 Associated Mucormycosis: Present Status and Future Perspectives.2019冠状病毒病相关毛霉病的当前治疗选择：现状与未来展望
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A mucormycosis case treated with a combination of caspofungin and amphotericin B.一例联合使用卡泊芬净和两性霉素 B 治疗的毛霉菌病。
J Mycol Med. 2013 Sep;23(3):179-84. doi: 10.1016/j.mycmed.2013.06.003. Epub 2013 Jul 12.
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