Hung Tsung Hsing, Tsai Chen Chi, Hsieh Yu Hsi, Tsai Chih Chun
Department of Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.
Turk J Gastroenterol. 2015 Mar;26(2):159-62. doi: 10.5152/tjg.2015.4829.
BACKGROUND/AIMS: There is no nationwide population-based study for the long-term mortality after single episode of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. Our study showed the short-term and long-term mortalities, and identified the mortality risk of SBP.
The National Health Insurance Database, derived from the Taiwan National Health Insurance program, was used to collect data from 16,992 cirrhotic patients. These cirrhotic patients were classified into three groups: SBP group (n=451, 2.7%), ascites without SBP group (n=2,564, 15.1%), and non-ascites (n=13,977, 82.3%) group. Each patient was followed up to 3 years after the initial hospitalization.
The 30-day mortalities in SBP, ascites without SBP, and non-ascites groups were 24.2%, 14.1%, and 8.1%, respectively. The 3-year mortalities in SBP, ascites without SBP, and non-ascites groups were 66.5%, 61.1%, and 41.5%. After Cox's regression analysis adjusted by the patients' age, gender, and underlying medical disorders, the SBP patients (hazard ratio=2.52) and ascites without SBP patients (hazard ratio=1.91) have higher risk for 3-year mortality than those without ascites.
Cirrhotic patients with SBP have a 2.5-fold increase of 3-year mortality, compared to those without ascites.
背景/目的：目前尚无基于全国人口的关于肝硬化患者单次自发性细菌性腹膜炎（SBP）后长期死亡率的研究。我们的研究显示了短期和长期死亡率，并确定了SBP的死亡风险。
使用源自台湾国民健康保险计划的国民健康保险数据库收集16992例肝硬化患者的数据。这些肝硬化患者被分为三组：SBP组（n = 451，2.7%）、无SBP的腹水组（n = 2564，15.1%）和无腹水组（n = 13977，82.3%）。对每位患者在首次住院后随访3年。
SBP组、无SBP的腹水组和无腹水组的30天死亡率分别为24.2%、14.1%和8.1%。SBP组、无SBP的腹水组和无腹水组的3年死亡率分别为66.5%、61.1%和41.5%。在根据患者年龄、性别和基础疾病进行Cox回归分析后，SBP患者（风险比=2.52）和无SBP的腹水患者（风险比=1.91）的3年死亡风险高于无腹水患者。
与无腹水的肝硬化患者相比，患有SBP的肝硬化患者3年死亡率增加2.5倍。
