Bannister P, Barnes I
Department of Geriatrics, Bristol Royal Infirmary, UK.
Gerontology. 1989;35(4):225-9. doi: 10.1159/000213027.
The investigation of thyroid disease in the elderly is difficult. Conventional tests are influenced by ill health and abnormal concentrations of thyroid binding proteins. To screen for thyroid disease thyroxine (T4), then tri-iodothyronine (T3) or TSH and an index for binding proteins are normally measured, methods which are expensive and time-consuming. TSH immunoradiometric assays (IRMA) offer the potential of a single test assessment of thyroid function in the elderly. This was assessed by comparing the measurement of IRMA-TSH with T4, T3 and the free thyroxine indices in 290 elderly subjects. Concordant results were obtained in 236 subjects. Non-concordant results were seen in 54 subjects. The commonest cause was sick euthyroid syndrome but 4 cases of high T4 and normal TSH were seen with amiodarone therapy.
对老年人甲状腺疾病进行调查很困难。传统检测会受到健康状况不佳以及甲状腺结合蛋白浓度异常的影响。为筛查甲状腺疾病，通常会检测甲状腺素（T4），然后是三碘甲状腺原氨酸（T3）或促甲状腺激素（TSH）以及结合蛋白指数，这些方法既昂贵又耗时。促甲状腺激素免疫放射分析（IRMA）为老年人甲状腺功能的单项检测评估提供了可能。通过比较290名老年受试者的IRMA - TSH测量值与T4、T3及游离甲状腺素指数对此进行了评估。236名受试者获得了一致结果。54名受试者出现了不一致结果。最常见的原因是病态甲状腺功能正常综合征，但胺碘酮治疗时出现了4例T4升高而TSH正常的情况。
