Linhart W E, Zadravec S, Esterbauer H, Weybora W, Pfeiffer K P
Department of Paediatric Surgery, University of Graz.
Free Radic Res Commun. 1989;7(3-6):325-33. doi: 10.3109/10715768909087958.
The effect of SOD on staphylococcal arthritis has not been successfully evaluated to date. We developed an animal model to investigate the correlation. Using 16 rabbits divided into four groups, we injected two groups with staphylococcus aureus and the other two with NaCl. One group in each was also injected with SOD. The presence of SOD activity in untreated and infected knee joints of rabbits over a period of 72 hours showed no significant difference. TBA-reactive substances (TBARS) measured in joint fluid and plasma did differ in each of the groups, with the highest values found in animals with septic arthritis treated with SOD. This finding corresponded especially with the histological investigation. Joints of infected animals intra-articularly injected with SOD also showed histologically significantly more inflammation, a higher amount of bacteria in the joint cavity, and more distinct joint damage than joints injected only with bacteria. The mechanisms responsible for this SOD effect remain to be determined.
迄今为止，超氧化物歧化酶（SOD）对葡萄球菌性关节炎的影响尚未得到成功评估。我们建立了一个动物模型来研究这种相关性。我们将16只兔子分为四组，给其中两组注射金黄色葡萄球菌，另外两组注射氯化钠。每组中的一组还注射了SOD。在72小时内，未治疗和感染的兔子膝关节中SOD活性的存在没有显著差异。在关节液和血浆中测量的硫代巴比妥酸反应性物质（TBARS）在每组中确实有所不同，在用SOD治疗的败血症性关节炎动物中发现的值最高。这一发现尤其与组织学研究一致。关节内注射SOD的感染动物的关节在组织学上也显示出明显更多的炎症、关节腔内更多的细菌以及比仅注射细菌的关节更明显的关节损伤。这种SOD效应的作用机制仍有待确定。
