Linhart W E, Spendel S, Weber G, Zadravec S
Department of Pediatric Surgery, University of Graz, Austria.
Z Versuchstierkd. 1990;33(2):65-71.
An experimental animal model for bacterial joint inflammation has been tested. Using 16 rabbits divided into 4 groups, we injected knee joints of two groups with Staphylococcus aureus and the other 2 with NaCl. One group in each was also injected with superoxide dismutase (SOD). A technique was developed which allowed frequent standardized aspirations of the joints carried out through the patella tendon. By this means, we aspirated 16 joints 112 times over 72 h, obtaining estimates of the activity of intra-articularly injected SOD. TBA-reactive substances (TBARS) measured in joint fluid and plasma were different in each of the groups, with the highest values found in animals with septic arthritis treated with SOD. Leucocyte and differential blood cell counts were checked at 12 hour intervals.
一种用于细菌性关节炎症的实验动物模型已经过测试。我们将16只兔子分成4组，给其中两组的膝关节注射金黄色葡萄球菌，另外两组注射氯化钠。每组中又有一组同时注射超氧化物歧化酶（SOD）。我们开发了一种技术，通过髌腱对关节进行频繁的标准化抽吸。通过这种方式，我们在72小时内对16个关节进行了112次抽吸，以评估关节内注射SOD的活性。在关节液和血浆中测量的硫代巴比妥酸反应性物质（TBARS）在每组中都有所不同，在接受SOD治疗的脓毒性关节炎动物中发现的值最高。每隔12小时检查白细胞和血细胞分类计数。
