Kameyama Mitsuhiro, Yabata Junko, Nomura Yasuharu, Tominaga Kiyoshi
Department of Health Science, Yamaguchi Prefectural Institute of Public Health and Environment, 2-5-67 Aoi, Yamaguchi 753-0821, Japan.
Department of Health Science, Yamaguchi Prefectural Institute of Public Health and Environment, 2-5-67 Aoi, Yamaguchi 753-0821, Japan.
J Infect Chemother. 2015 Jul;21(7):544-6. doi: 10.1016/j.jiac.2015.03.004. Epub 2015 Mar 12.
In 2013, an outbreak of enterohemorrhagic Escherichia coli (EHEC) O157:H7 occurred in a nursery school in Japan. The outbreak affected 12 school children and five members of their families. All 17 isolates obtained from these individuals were found to be clonal, as determined by pulsed-field gel electrophoresis analysis and multilocus variable number tandem repeat analysis. The antimicrobial susceptibility profiles of the isolates to 20 drugs were examined, with three isolates showing resistance to the extended-spectrum cephalosporins (ESC) and cephamycin, including cefotaxime, ceftazidime, and cefminox. The resistant isolates carried the blaCMY-2 AmpC β-lactamase gene. It is proposed that the ESC-resistant EHEC O157:H7 isolates might have acquired the resistance plasmid encoding the blaCMY-2 gene during human to human infection in the nursery school.
2013年，日本一所幼儿园爆发了肠出血性大肠杆菌（EHEC）O157:H7感染疫情。此次疫情影响了12名学童及其5名家庭成员。通过脉冲场凝胶电泳分析和多位点可变数目串联重复分析确定，从这些个体中分离出的所有17株菌株均为克隆菌株。检测了这些菌株对20种药物的抗菌药敏谱，其中3株菌株对广谱头孢菌素（ESC）和头孢霉素耐药，包括头孢噻肟、头孢他啶和头孢米诺。耐药菌株携带blaCMY-2 AmpCβ-内酰胺酶基因。有人提出，耐ESC的EHEC O157:H7菌株可能是在幼儿园人际感染期间获得了编码blaCMY-2基因的耐药质粒。
