Ten Brink Antonia F, Nijboer Tanja C W, Bergsma Douwe P, Barton Jason J S, Van der Stigchel Stefan
Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands; Brain Center Rudolf Magnus Institute of Neuroscience and Centre of Excellence for Rehabilitation Medicine, University Medical Centre Utrecht and Rehabilitation Centre De Hoogstraat, Utrecht, The Netherlands.
University Medical Centre St. Radboud, department of Cognitive Neuroscience, Nijmegen, The Netherlands.
PLoS One. 2015 Apr 2;10(4):e0122054. doi: 10.1371/journal.pone.0122054. eCollection 2015.
In patients with visual hemifield defects residual visual functions may be present, a phenomenon called blindsight. The superior colliculus (SC) is part of the spared pathway that is considered to be responsible for this phenomenon. Given that the SC processes input from different modalities and is involved in the programming of saccadic eye movements, the aim of the present study was to examine whether multimodal integration can modulate oculomotor competition in the damaged hemifield. We conducted two experiments with eight patients who had visual field defects due to lesions that affected the retinogeniculate pathway but spared the retinotectal direct SC pathway. They had to make saccades to an auditory target that was presented alone or in combination with a visual stimulus. The visual stimulus could either be spatially coincident with the auditory target (possibly enhancing the auditory target signal), or spatially disparate to the auditory target (possibly competing with the auditory tar-get signal). For each patient we compared the saccade endpoint deviation in these two bi-modal conditions with the endpoint deviation in the unimodal condition (auditory target alone). In all seven hemianopic patients, saccade accuracy was affected only by visual stimuli in the intact, but not in the blind visual field. In one patient with a more limited quadrantano-pia, a facilitation effect of the spatially coincident visual stimulus was observed. We conclude that our results show that multisensory integration is infrequent in the blind field of patients with hemianopia.
在患有视野半侧缺损的患者中，可能存在残余视觉功能，这一现象称为盲视。上丘（SC）是被认为对此现象负责的保留通路的一部分。鉴于上丘处理来自不同模态的输入并参与眼球扫视运动的编程，本研究的目的是检查多模态整合是否能调节受损半视野中的眼球运动竞争。我们对八名因病变影响视网膜膝状体通路但保留视网膜顶盖直接上丘通路而患有视野缺损的患者进行了两项实验。他们必须对单独呈现或与视觉刺激结合呈现的听觉目标进行扫视。视觉刺激可以与听觉目标在空间上重合（可能增强听觉目标信号），或者与听觉目标在空间上不同（可能与听觉目标信号竞争）。对于每位患者，我们将这两种双模态条件下的扫视终点偏差与单模态条件（仅听觉目标）下的终点偏差进行了比较。在所有七名偏盲患者中，扫视准确性仅受完整视野而非盲视野中的视觉刺激影响。在一名象限盲范围更有限的患者中，观察到了空间重合视觉刺激的促进作用。我们得出结论，我们的结果表明，多感官整合在偏盲患者的盲视野中并不常见。
