Vivero Marina, Padera Robert F
Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Rheum Dis Clin North Am. 2015 May;41(2):197-211. doi: 10.1016/j.rdc.2014.12.002. Epub 2015 Feb 27.
The pathologic correlates of interstitial lung disease (ILD) secondary to connective tissue disease (CTD) comprise a diverse group of histologic patterns. Lung biopsies in patients with CTD-associated ILD tend to demonstrate simultaneous involvement of multiple anatomic compartments of the lung. Certain histologic patterns tend to predominate in each defined CTD, and it is possible in many cases to confirm connective tissue-associated lung disease and guide patient management using surgical lung biopsy. This article will cover the pulmonary pathologies seen in rheumatoid arthritis, systemic sclerosis, myositis, systemic lupus erythematosus, Sjögren syndrome, and mixed CTD.
结缔组织病（CTD）继发的间质性肺疾病（ILD）的病理表现包括多种不同的组织学模式。CTD相关ILD患者的肺活检往往显示肺的多个解剖区域同时受累。在每种特定的CTD中，某些组织学模式往往占主导地位，在许多情况下，通过外科肺活检有可能确诊结缔组织相关的肺病并指导患者的治疗。本文将涵盖类风湿关节炎、系统性硬化症、肌炎、系统性红斑狼疮、干燥综合征和混合性CTD中所见的肺部病变。
