Verma-Ansil B, Carmichael F J, Saldivia V, Varghese G, Orrego H
Department of Anaesthesia, University of Toronto, Ontario, Canada.
Hepatology. 1989 Dec;10(6):946-52. doi: 10.1002/hep.1840100609.
Alcoholic liver disease is frequently accompanied by portal hypertension. We have previously shown that alcohol intake in awake, unrestrained rats is followed by an increase in portal tributary blood flow. In this study, the effect of ethanol on splanchnic hemodynamics in rats with portal hypertension was analyzed. Portal hypertension was induced by partial ligation of the portal vein. This procedure resulted in an increase in portal tributary and hepatic arterial blood flows compared to sham-operated animals. Ethanol (2 gm per kg, oral) increased portal tributary blood flow in both sham-operated and portal vein-ligated rats (sham + water = 37.6 +/- 1.4; sham + ethanol = 63.1 +/- 1.9; p less than 0.01; partial portal vein stenosis + water = 53.2 +/- 3.3; partial portal vein stenosis + ethanol = 69.5 +/- 2.2 ml.kg-1.min-1; p less than 0.01). In sham-operated rats, hepatic artery blood flow was unchanged following ethanol (sham + water = 6.6 +/- 0.7; sham + ethanol = 7.1 +/- 1.0 ml.kg-1.min-1), whereas in portal vein-ligated rats, flow was increased (partial portal vein stenosis + water = 13.7 +/- 1.4; partial portal vein stenosis + ethanol = 19.8 +/- 1.1 ml.kg-1.min-1; p less than 0.025). The adenosine receptor blocker 8-phenyltheophylline suppressed only the ethanol-induced increase in both portal tributary and hepatic artery blood flows in portal vein-ligated rats. The increases in hepatic artery and portal tributary blood flows observed in portal vein-ligated rats without ethanol were not influenced by 8-phenyltheophylline.(ABSTRACT TRUNCATED AT 250 WORDS)
酒精性肝病常伴有门静脉高压。我们之前已表明，清醒、未受限制的大鼠摄入酒精后，门静脉分支血流会增加。在本研究中，分析了乙醇对门静脉高压大鼠内脏血流动力学的影响。门静脉高压通过门静脉部分结扎诱导产生。与假手术动物相比，该操作导致门静脉分支和肝动脉血流增加。乙醇（2克/千克，口服）使假手术大鼠和门静脉结扎大鼠的门静脉分支血流均增加（假手术+水=37.6±1.4；假手术+乙醇=63.1±1.9；p＜0.01；部分门静脉狭窄+水=53.2±3.3；部分门静脉狭窄+乙醇=69.5±2.2毫升·千克⁻¹·分钟⁻¹；p＜0.01）。在假手术大鼠中，乙醇摄入后肝动脉血流未改变（假手术+水=6.6±0.7；假手术+乙醇=7.1±1.0毫升·千克⁻¹·分钟⁻¹），而在门静脉结扎大鼠中，血流增加（部分门静脉狭窄+水=13.7±1.4；部分门静脉狭窄+乙醇=19.8±1.1毫升·千克⁻¹·分钟⁻¹；p＜0.025）。腺苷受体阻滞剂8-苯基茶碱仅抑制门静脉结扎大鼠中乙醇诱导的门静脉分支和肝动脉血流增加。在未摄入乙醇的门静脉结扎大鼠中观察到的肝动脉和门静脉分支血流增加不受8-苯基茶碱影响。（摘要截选于250字）
