先天性梅毒中的类风湿因子。
Rheumatoid factor in congenital syphilis.
作者信息
Meyer M P, Malan A F
机构信息
Department of Paediatrics and Child Health, University of Cape Town, South Africa.
出版信息
Genitourin Med. 1989 Oct;65(5):304-7. doi: 10.1136/sti.65.5.304.
The rheumatoid factor (RF) latex test was evaluated as a test for congenital syphilis. High risk newborns of mothers with untreated or inadequately treated syphilis were studied. The asymptomatic infants were followed up for between 3 and 4 months (or longer if the VDRL test was positive). The overall performance of the RF latex test was better than that of the other tests studied, even though the sensitivity was 46.7%. The specificity and positive predictive value of the test were 100% whilst the negative predictive value was 86.4%. The test was negative in all 84 controls studied. Although a negative RF latex test cannot be used to exclude congenital syphilis in an asymptomatic infant, a positive test in the presence of maternal syphilis should lead one to strongly suspect congenital syphilis.
类风湿因子（RF）乳胶试验被评估作为先天性梅毒的一项检测方法。对患有未经治疗或治疗不充分梅毒的母亲所生的高危新生儿进行了研究。对无症状婴儿进行了3至4个月的随访（如果VDRL试验呈阳性，则随访时间更长）。尽管RF乳胶试验的敏感性为46.7%，但其总体表现优于所研究的其他检测方法。该试验的特异性和阳性预测值为100%，而阴性预测值为86.4%。在所研究的全部84名对照中，该试验均为阴性。虽然阴性的RF乳胶试验不能用于排除无症状婴儿的先天性梅毒，但在母亲患有梅毒的情况下呈阳性试验结果应使人强烈怀疑先天性梅毒。
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