Wan Yizao, Wu Chaoqun, Xiong Guangyao, Zuo Guifu, Jin Jun, Ren Kaijing, Zhu Yong, Wang Zheren, Luo Honglin
School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China.
School of Mechanical and Electrical Engineering, East China Jiaotong University, Nanchang 330013, China.
J Mech Behav Biomed Mater. 2015 Jul;47:29-37. doi: 10.1016/j.jmbbm.2015.03.009. Epub 2015 Mar 19.
Hydroxyapatite (HAp) in the forms of fiber, needle, and whisker has been employed as fillers in polymer composites. Herein, nanoplate-like HAp synthesized by template-assisted self-assembly was used to reinforce polylactide (PLA) nanocomposites via the solution intercalation method. Dynamic and static mechanical properties and cytotoxicity of the as-prepared HAp/PLA nanocomposites were assessed in addition to characterizations by XRD, FTIR, and TGA. XRD analysis confirms the formation of exfoliated structure in the HAp/PLA nanocomposites. The HAp/PLA nanocomposites exhibit better static and dynamic mechanical properties than unreinforced PLA. Furthermore, the HAp/PLA nanocomposite with an optimum HAp content of 20wt% (20HAp/PLA) demonstrates not only the best mechanical performance but also the highest thermal stability among the nanocomposite samples. Cell studies using a mouse fibroblast cell line (L929) suggest that 20HAp/PLA shows excellent biocompatibility, which makes it a promising material for biomedical applications.
纤维状、针状和晶须状的羟基磷灰石（HAp）已被用作聚合物复合材料的填料。在此，通过模板辅助自组装合成的纳米片状HAp通过溶液插层法用于增强聚乳酸（PLA）纳米复合材料。除了通过XRD、FTIR和TGA进行表征外，还评估了所制备的HAp/PLA纳米复合材料的动态和静态力学性能以及细胞毒性。XRD分析证实了HAp/PLA纳米复合材料中形成了剥离结构。HAp/PLA纳米复合材料表现出比未增强的PLA更好的静态和动态力学性能。此外，HAp含量为20wt%的最佳HAp/PLA纳米复合材料（20HAp/PLA）不仅在纳米复合材料样品中表现出最佳的力学性能，还具有最高的热稳定性。使用小鼠成纤维细胞系（L929）进行的细胞研究表明，20HAp/PLA具有优异的生物相容性，这使其成为生物医学应用中有前景的材料。
