Shokrollahi Parvin, Mehmanchi Mohammad, Atai Mohammad, Omidian Hossein, Shokrolahi Fateme
Department of Biomaterials, Iran Polymer and Petrochemical Institute, P.O. Box 14965/159, Tehran, Iran,
J Mater Sci Mater Med. 2014 Jan;25(1):23-35. doi: 10.1007/s10856-013-5039-6. Epub 2013 Sep 13.
This research explores the correlation between the structural properties of supramolecular biocomposites and their mechanical strength. Hybrid biocomposites composed of surface-modified hydroxyapatite nano-particles and supramolecular polycaprolactone (SP PCL), were prepared at different compositions, and their mechanical, thermal and viscoelastic properties as well as biodegradability, biocompatibility and cytotoxicity were evaluated in vitro. The results were compared with those for SP PCL/naked hydroxyapatite nano-composites. We show that surface modification of hydroxyapatite nanoparticles resulted in outstanding improvement of tensile strength and modulus up to 3.6 and 2.2-fold, respectively. At above 10 wt% HAp and 20 wt% HApUPy, heterogeneous nano-composites with inferior mechanical properties were obtained. Based on rheological (in steady shear mode) and small/wide angle X-ray scattering measurements, unusual improved mechanical properties were ascribed to the formation of supramolecular clusters around nanoparticles. In-vitro degradation of the supramolecular nano-composites was also studied to investigate the overall product biodegradation as well as toxicity of the degradation product(s).
本研究探讨了超分子生物复合材料的结构特性与其机械强度之间的相关性。制备了由表面改性的羟基磷灰石纳米颗粒和超分子聚己内酯（SP PCL）组成的杂化生物复合材料，其组成各不相同，并在体外评估了它们的机械、热和粘弹性特性以及生物降解性、生物相容性和细胞毒性。将结果与SP PCL/裸羟基磷灰石纳米复合材料的结果进行了比较。我们表明，羟基磷灰石纳米颗粒的表面改性分别使拉伸强度和模量显著提高了3.6倍和2.2倍。当HAp含量高于10 wt%且HApUPy含量高于20 wt%时，会得到机械性能较差的非均相纳米复合材料。基于流变学（稳态剪切模式）以及小角/广角X射线散射测量，异常改善的机械性能归因于纳米颗粒周围超分子簇的形成。还研究了超分子纳米复合材料的体外降解，以研究整体产品的生物降解以及降解产物的毒性。
