Peng Song, Zhang Lian, Hu Liang, Chen Jinyun, Ju Jin, Wang Xi, Zhang Rong, Wang Zhibiao, Chen Wenzhi
From the State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology (SP, LZ, LH, JC, ZW), Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University; HIFU Center for Tumor Therapy (JJ, XW, RZ), 1st Affiliated Hospital of Chongqing Medical University; and Clinical Center for Tumor Therapy (WC), 2nd Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Medicine (Baltimore). 2015 Apr;94(13):e650. doi: 10.1097/MD.0000000000000650.
The aim of this article is to analyze factors affecting sonication dose and build a dosimetry model of high-intensity focused ultrasound (HIFU) ablation for uterine fibroids. Four hundred and three patients with symptomatic uterine fibroids who underwent HIFU were retrospectively analyzed. The energy efficiency factor (EEF) was set as dependent variable, and the factors possibly affecting sonication dose included age, body mass index, size of uterine fibroid, abdominal wall thickness, the distance from uterine fibroid dorsal side to sacrum, the distance from uterine fibroid ventral side to skin, location of uterus, location of uterine fibroids, type of uterine fibroids, abdominal wall scar, signal intensity on T2-weighted imaging (T2WI), and enhancement type on T1-weighted imaging (T1WI) were set as predictors to build a multiple regression model. The size of uterine fibroid, distance from fibroid ventral side to skin, location of uterus, location of uterine fibroids, type of uterine fibroids, signal intensity on T2WI, and enhancement type on T1WI had a linear correlation with EEF. The distance from fibroid ventral side to skin, enhancement type on T1WI, size of uterine fibroid, and signal intensity on T2WI were eventually incorporated into the dosimetry model. The distance from fibroid ventral side to skin, enhancement type on T1WI, size of uterine fibroid, and signal intensity on T2WI can be used as dosimetric predictors for HIFU for uterine fibroids.
本文旨在分析影响超声剂量的因素，并建立子宫肌瘤高强度聚焦超声（HIFU）消融的剂量学模型。对403例行HIFU治疗的有症状子宫肌瘤患者进行回顾性分析。将能量效率因子（EEF）设为因变量，将可能影响超声剂量的因素包括年龄、体重指数、子宫肌瘤大小、腹壁厚度、子宫肌瘤背侧至骶骨的距离、子宫肌瘤腹侧至皮肤的距离、子宫位置、子宫肌瘤位置、子宫肌瘤类型、腹壁瘢痕、T2加权成像（T2WI）信号强度以及T1加权成像（T1WI）强化类型设为预测因子，建立多元回归模型。子宫肌瘤大小、肌瘤腹侧至皮肤的距离、子宫位置、子宫肌瘤位置、子宫肌瘤类型、T2WI信号强度以及T1WI强化类型与EEF呈线性相关。最终将肌瘤腹侧至皮肤的距离、T1WI强化类型、子宫肌瘤大小以及T2WI信号强度纳入剂量学模型。肌瘤腹侧至皮肤的距离、T1WI强化类型、子宫肌瘤大小以及T2WI信号强度可作为子宫肌瘤HIFU治疗的剂量学预测指标。
