Madeo Dario, Castellani Eleonora, Mocenni Chiara, Santarcangelo Enrica Laura
Department of Information Engineering and Mathematical Sciences, Italy; Complex Systems Community, University of Siena, Siena, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Physiol Behav. 2015 Jun 1;145:57-63. doi: 10.1016/j.physbeh.2015.03.040. Epub 2015 Mar 30.
We report novel findings concerning the role of hypnotizability, suggestions of analgesia and the activity of the Behavioral Inhibition/Activation System (BIS/BAS) in the modulation of the subjective experience of pain and of the associated EEG dynamics. The EEG of high (highs) and low hypnotizable participants (lows) who completed the BIS/BAS questionnaire was recorded during basal conditions, tonic nociceptive stimulation without (PAIN) and with suggestions for analgesia (AN). Participants scored the perceived pain intensity at the end of PAIN and AN. The EEG midline dynamics was characterized by indices indicating the signal predictability (Determinism) and complexity (Entropy) obtained through the Recurrence Quantification Analysis. The reduced pain intensity reported by highs during AN was partially accounted for by the activity of the Behavioral Activation System. The decreased midline cortical Determinism observed during nociceptive stimulation in both groups independently of suggestions remained significantly reduced only in lows after controlling for the activity of the Behavioral Activation System. Finally, controlling for the activity of the Behavioral Inhibition System abolished stimulation, suggestions and hypnotizability-related differences. Results indicate that the BIS/BAS activity may be more important than hypnotizability itself in pain modulation and in the associated EEG dynamics.
我们报告了关于催眠易感性、镇痛暗示以及行为抑制/激活系统（BIS/BAS）在调节疼痛主观体验和相关脑电图动态方面作用的新发现。在基础状态、无镇痛暗示的持续性伤害性刺激（PAIN）以及有镇痛暗示（AN）的情况下，记录完成BIS/BAS问卷的高催眠易感性参与者（highs）和低催眠易感性参与者（lows）的脑电图。参与者在PAIN和AN结束时对感知到的疼痛强度进行评分。脑电图中线动态通过循环量化分析获得的指示信号可预测性（确定性）和复杂性（熵）的指标来表征。在AN期间，highs报告的疼痛强度降低部分归因于行为激活系统的活动。两组在伤害性刺激期间观察到的中线皮质确定性降低，无论有无暗示，在控制行为激活系统的活动后，只有lows组仍显著降低。最后，控制行为抑制系统的活动消除了刺激、暗示和催眠易感性相关的差异。结果表明，在疼痛调节和相关脑电图动态方面，BIS/BAS活动可能比催眠易感性本身更重要。
