Sapienza Università di Roma, Dipartimento di Psicologia, Italy.
Cortex. 2013 Feb;49(2):446-62. doi: 10.1016/j.cortex.2012.02.005. Epub 2012 Feb 22.
Neuroimaging studies indicate that hypnotic suggestions of increased and decreased pain intensity and unpleasantness may modulate somatosensory and cingulate cortex activity, respectively.
Using a within subject design and a strict subject selection procedure, we tested in High (Highs) and Low (Lows) hypnotically suggestible individuals whether hypnotic suggestions of sensory and affective hypoalgesia or hyperalgesia differentially affected subjective ratings of laser-induced pain and nociceptive-related brain activity in the time- and time-frequency domain.
Hypnotic modulation of pain intensity and unpleasantness affected subjective ratings of laser-induced pain only in Highs. Such modulation was more specific for unpleasantness manipulation and more evident for suggestions of hyperalgesia. Importantly, Highs and Lows showed increase and decrease of P2a and P2b wave amplitudes and gamma band power, respectively.
Hypnotic suggestions exerted a top-down modulatory effect on both evoked and induced-cortical brain responses triggered by selective nociceptive laser inputs. Furthermore, correlation analyses indicated that gamma power modulation and suggestions of hyperalgesia may reflect the process of allocating control resources to salient and threatening sensory-affective dimensions of pain.
神经影像学研究表明，催眠暗示的疼痛强度和不愉快感的增加和减少可能分别调节体感和扣带皮层的活动。
使用个体内设计和严格的个体选择程序，我们在高（Highs）和低（Lows）催眠暗示个体中测试，催眠暗示的感觉和情感镇痛或痛觉过敏是否会分别影响激光诱导疼痛的主观评分和痛觉相关脑活动的时间和时频域。
催眠对疼痛强度和不愉快感的调节仅在 Highs 中影响激光诱导疼痛的主观评分。这种调节对于不愉快感的操纵更为特定，对于痛觉过敏的暗示更为明显。重要的是，Highs 和 Lows 分别表现出 P2a 和 P2b 波幅度和伽马频带功率的增加和减少。
催眠暗示对选择性伤害性激光输入触发的诱发和诱导皮层脑反应产生了自上而下的调节作用。此外，相关分析表明，伽马功率调节和痛觉过敏的暗示可能反映了将控制资源分配给疼痛的显著和威胁性感觉-情感维度的过程。
