Department of Medicine, Stanford University School of Medicine, Stanford, California, USA, and the Geriatric Research, Education and Clinical Center, Palo Alto Veterans Affairs Health Care System Health Care System, Palo Alto, California, USA.
Nat Struct Mol Biol. 2015 Apr;22(4):275-7. doi: 10.1038/nsmb.3004.
Circadian regulation of epigenetic chromatin marks drives daily transcriptional oscillation of thousands of genes and is intimately linked to cellular metabolism and bioenergetics. New work links circadian fluctuations in the activity of the SIRT1 deacetylase, a sensor of the cellular energy state, to histone-methylation changes and the circadian expression of clock-controlled genes.
生物钟调节表观遗传染色质标记，驱动数千个基因的日常转录振荡，与细胞代谢和生物能量密切相关。新的研究将 SIRT1 去乙酰化酶（细胞能量状态的传感器）活性的生物钟波动与组蛋白甲基化变化和生物钟控制基因的表达联系起来。
