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十二指肠溃疡穿孔引发的甲状腺危象。

Thyroid storm precipitated by duodenal ulcer perforation.

作者信息

Natsuda Shoko, Nakashima Yomi, Horie Ichiro, Ando Takao, Kawakami Atsushi

机构信息

Department of Endocrinology and Metabolism, Nagasaki University Hospital, Nagasaki 852-8501, Japan.

出版信息

Case Rep Endocrinol. 2015;2015:750390. doi: 10.1155/2015/750390. Epub 2015 Mar 9.

DOI:10.1155/2015/750390
PMID:25838951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4369934/
Abstract

Thyroid storm is a rare and life-threatening complication of thyrotoxicosis that requires prompt treatment. Thyroid storm is also known to be associated with precipitating events. The simultaneous treatment of thyroid storm and its precipitant, when they are recognized, in a patient is recommended; otherwise such disorders, including thyroid storm, can exacerbate each other. Here we report the case of a thyroid storm patient (a 55-year-old Japanese male) complicated with a perforated duodenal ulcer. The patient was successfully treated with intensive treatment for thyroid storm and a prompt operation. Although it is believed that peptic ulcer rarely coexists with hyperthyroidism, among patients with thyroid storm, perforation of a peptic ulcer has been reported as one of the causes of fatal outcome. We determined that surgical intervention was required in this patient, reported despite ongoing severe thyrotoxicosis, and reported herein a successful outcome.

摘要

甲状腺危象是甲状腺毒症一种罕见且危及生命的并发症,需要及时治疗。甲状腺危象也已知与诱发事件有关。建议在患者中同时识别并治疗甲状腺危象及其诱发因素;否则,包括甲状腺危象在内的此类疾病会相互加重。在此,我们报告一例甲状腺危象患者(一名55岁日本男性)并发十二指肠溃疡穿孔的病例。该患者通过甲状腺危象强化治疗和及时手术成功治愈。尽管一般认为消化性溃疡很少与甲状腺功能亢进并存,但在甲状腺危象患者中,消化性溃疡穿孔已被报道为致命结局的原因之一。我们确定该患者尽管存在严重甲状腺毒症仍需要进行手术干预,并在此报告了成功的治疗结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/532a/4369934/b7404f248fbe/CRIE2015-750390.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/532a/4369934/b7404f248fbe/CRIE2015-750390.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/532a/4369934/b7404f248fbe/CRIE2015-750390.001.jpg

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本文引用的文献

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Clinical features and hospital outcomes in thyroid storm: a retrospective cohort study.甲状腺危象的临床特征与住院结局:一项回顾性队列研究
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Comparison of gastroduodenal ulcer incidence in healthy Japanese subjects taking celecoxib or loxoprofen evaluated by endoscopy: a placebo-controlled, double-blind 2-week study.内镜评估的健康日本受试者中塞来昔布或洛索洛芬的胃十二指肠溃疡发生率比较:一项安慰剂对照、双盲 2 周研究。
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Guidelines for prevention of NSAID-related ulcer complications.非甾体抗炎药相关性溃疡并发症的预防指南。
Am J Gastroenterol. 2009 Mar;104(3):728-38. doi: 10.1038/ajg.2009.115. Epub 2009 Feb 24.
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Successful treatment of gastric perforation with thyrotoxic crisis.甲状腺危象合并胃穿孔的成功治疗
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Experience with acute perforated duodenal ulcer in a West African population.西非人群急性十二指肠溃疡穿孔的经验
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Thyrotoxicosis and acute abdomen--still as defying and misunderstood today? Brief observations over the recent decade.甲状腺毒症与急腹症——如今仍如此难以捉摸且被误解吗?近十年的简要观察
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