Sumagin Ronen, Parkos Charles A
Department of Pathology and Laboratory Medicine; Epithelial Pathobiology and Mucosal Inflammation Unit; Emory University ; Atlanta, GA USA.
Tissue Barriers. 2015 Apr 3;3(1-2):e969100. doi: 10.4161/21688362.2014.969100. eCollection 2015.
Epithelial adhesion molecules play essential roles in regulating cellular function and maintaining mucosal tissue homeostasis. Some form epithelial junctional complexes to provide structural support for epithelial monolayers and act as a selectively permeable barrier separating luminal contents from the surrounding tissue. Others serve as docking structures for invading viruses and bacteria, while also regulating the immune response. They can either obstruct or serve as footholds for the immune cells recruited to mucosal surfaces. Currently, it is well appreciated that adhesion molecules collectively serve as environmental cue sensors and trigger signaling events to regulate epithelial function through their association with the cell cytoskeleton and various intracellular adapter proteins. Immune cells, particularly neutrophils (PMN) during transepithelial migration (TEM), can modulate adhesion molecule expression, conformation, and distribution, significantly impacting epithelial function and tissue homeostasis. This review discusses the roles of key intestinal epithelial adhesion molecules in regulating PMN trafficking and outlines the potential consequences on epithelial function.
上皮黏附分子在调节细胞功能和维持黏膜组织稳态中发挥着重要作用。一些上皮黏附分子形成上皮连接复合体，为上皮单层提供结构支持，并作为选择性渗透屏障，将管腔内容物与周围组织分隔开来。其他上皮黏附分子则作为入侵病毒和细菌的对接结构，同时还调节免疫反应。它们既可以阻碍募集到黏膜表面的免疫细胞，也可以作为这些免疫细胞的立足点。目前，人们已经充分认识到，黏附分子共同作为环境信号传感器，并通过与细胞骨架和各种细胞内衔接蛋白的结合触发信号事件，从而调节上皮功能。免疫细胞，尤其是在跨上皮迁移（TEM）过程中的中性粒细胞（PMN），可以调节黏附分子的表达、构象和分布，显著影响上皮功能和组织稳态。本综述讨论了关键肠道上皮黏附分子在调节PMN转运中的作用，并概述了对上皮功能的潜在影响。
