Nichols J F, Bigelow D M, Canine K M
Department of Physical Education, San Diego State University, CA 92182.
Int J Obes. 1989;13(5):683-90.
Our purpose was to examine the effect of short-term weight loss and exercise training on the thermic effect of a glucose load in lean and obese adolescents. Nine obese (age 14.3 +/- 0.3 years, mean +/- s.e.m.) boys were examined during the first (Ob-pre) and sixth (Ob-post) week of caloric restriction (1300-1500 kcal/day, 5441-6279 kJ/day) and aerobic exercise conditioning (walk/jog/swim/calisthenics), and compared to age-matched lean controls (Con). A 100-g oral glucose tolerance test (OGTT) was administered while simultaneously measuring energy expenditure by indirect calorimetry every 30 min for 3 h. Posttest results revealed a decrease in body weight and body fatness in obese boys, but not to the level of that in lean controls (P less than 0.01). The thermic effect of glucose, calculated as the area under the response curve for three hours in excess of resting metabolic rate, was similar in Ob-pre and Con (0.77 +/- 0.14 vs. 0.57 +/- 0.28 kcal/kg lbm/3h), but decreased in Ob-post (0.29 +/- 0.08 kcal/kg lbm/3h, P less than 0.01). The area under the response curve for glucose was elevated in Ob-pre (328.1 +/- 12.2 mg/dl/3h) compared to Con (270.4 +/- 21.4 mg/dl/3h). The insulin response was similar in Ob-pre and Con (120.4 +/- 11.3 vs 125.6 +/- 12.4 mU/ml/3h), but decreased in Ob-post (89.6 +/- 15.1 mU/ml/3h, P less than 0.05). Thus, the improvement in peripheral insulin sensitivity with short-term exercise and weight loss was unaccompanied by favorable alterations in carbohydrate-induced thermogenesis in obese adolescents.
我们的目的是研究短期体重减轻和运动训练对瘦和肥胖青少年葡萄糖负荷热效应的影响。九名肥胖男孩（年龄14.3±0.3岁，均值±标准误）在热量限制（1300 - 1500千卡/天，5441 - 6279千焦/天）和有氧运动训练（步行/慢跑/游泳/健身操）的第一周（Ob - pre）和第六周（Ob - post）接受检查，并与年龄匹配的瘦对照组（Con）进行比较。进行100克口服葡萄糖耐量试验（OGTT），同时每隔30分钟通过间接测热法测量3小时的能量消耗。测试后结果显示肥胖男孩体重和体脂减少，但未降至瘦对照组水平（P < 0.01）。葡萄糖的热效应，以超过静息代谢率的三小时反应曲线下面积计算，在Ob - pre组和Con组相似（0.77±0.14对0.57±0.28千卡/千克瘦体重/3小时），但在Ob - post组降低（0.29±0.08千卡/千克瘦体重/3小时，P < 0.01）。与Con组（270.4±21.4毫克/分升/3小时）相比，Ob - pre组葡萄糖反应曲线下面积升高（328.1±12.2毫克/分升/3小时）。胰岛素反应在Ob - pre组和Con组相似（120.4±11.3对125.6±12.4毫单位/毫升/3小时），但在Ob - post组降低（89.6±15.1毫单位/毫升/3小时，P < 0.05）。因此，肥胖青少年通过短期运动和体重减轻改善外周胰岛素敏感性时，碳水化合物诱导的产热并未出现有利变化。
