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Trophic effects of cholecystokinin and calcitonin gene-related peptide on ventral spinal cord in culture.

作者信息

Iwasaki Y, Kinoshita M, Ikeda K, Shiojima T

机构信息

Fourth Department of Internal Medicine Toho University Ohashi Hospital, Tokyo, Japan.

出版信息

Int J Neurosci. 1989 Oct;48(3-4):285-9. doi: 10.3109/00207458909002171.

DOI:10.3109/00207458909002171
PMID:2583943
Abstract

We studied trophic effects of cholecystokinin (CCK) and calcitonin gene-related peptide (CGRP) on explanted cultures of ventral spinal cord from 13-14 old day rat embryo. There was a significant neurite promoting effect (NPE) in CCK-treated culture. The neuritic extension of ventral spinal cord exceeds control values 3.5-6.5 times. Otherwise, CGRP and NPE at any concentration. The possible mechanism of trophic effect of CCK on ventral spinal cord was briefly discussed. Our results may contribute to a therapeutic strategy for amyotrophic lateral sclerosis.

摘要

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