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儿童与成人之间HIV-1 C亚型逆转录酶进化的差异可能由细胞毒性T淋巴细胞反应的成熟度来解释。

Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses.

作者信息

Saravanan Shanmugam, Gomathi Selvamurthi, Kausalya Bagavathi, Boobalan Jayaseelan, Murugavel Kailapuri G, Balakrishnan Pachamuthu, Mothi Sarvode N, Solomon Sunil S, Kumarasamy Nagalingeswaran, Selvamuthu Poongulali, Solomon Suniti, Smith Davey M

机构信息

1YRG CARE, Chennai, India.

2Asha Kirana Hospital, Mysore, India.

出版信息

AIDS Res Hum Retroviruses. 2015 Jun;31(6):655-7. doi: 10.1089/AID.2015.0023. Epub 2015 Apr 28.

DOI:10.1089/AID.2015.0023
PMID:25839730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4458742/
Abstract

In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.

摘要

在本研究中，感染HIV-1 C亚型的成年人在其病毒群体的逆转录酶（RT）上表现出比感染儿童更高的纯化选择。这种差异可能是由成年人中更成熟的细胞毒性T淋巴细胞反应所解释的，这可能对RT区域耐药性的发展有影响。

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