磷脂酶 A2 受体与结节病相关性膜性肾病。
Phospholipase A2 receptor and sarcoidosis-associated membranous nephropathy.
机构信息
Service de Néphrologie et Dialyse, Necker hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Service de Néphrologie et Transplantation, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Est Créteil (UPEC), Créteil, France INSERM U955, Equipe 21, Centre de Référence Syndrome Néphrotique Idiopathique, UPEC, Créteil, France.
出版信息
Nephrol Dial Transplant. 2015 Jun;30(6):1047-50. doi: 10.1093/ndt/gfv080. Epub 2015 Apr 2.
Of the glomerulonephritis associated with sarcoidosis, membranous nephropathy (MN) is the most prevalent. Coincidence or a causal relationship between these two diseases is unclear. Here, we present for the first time a high prevalence of PLA2R-related MN among patients with MN associated with active sarcoidosis. Our results suggest some causal link between sarcoidosis and PLA2R-related MN. Detection of anti-PLA2R antibodies in serum or PLA2R antigen in biopsy should not be taken as evidence against a secondary cause, particularly sarcoidosis. This important observation can affect treatment decision in these patients.
在与结节病相关的肾小球肾炎中，膜性肾病（MN）最为常见。这两种疾病是巧合还是存在因果关系尚不清楚。在这里，我们首次报道了在活动期结节病相关 MN 患者中 PLA2R 相关 MN 的高患病率。我们的结果表明结节病和 PLA2R 相关 MN 之间存在某种因果关系。在血清中检测到抗 PLA2R 抗体或在活检中检测到 PLA2R 抗原不应被视为继发原因的证据，尤其是结节病。这一重要观察结果可能会影响这些患者的治疗决策。
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