使用易得的二氟和单氟烷基亚磺酸钠，实现共轭 N-芳基磺酰胺的氟烷基芳基迁移。
Fluoroalkylative aryl migration of conjugated N-arylsulfonylated amides using easily accessible sodium di- and monofluoroalkanesulfinates.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.
出版信息
Org Lett. 2015 Apr 17;17(8):1838-41. doi: 10.1021/acs.orglett.5b00308. Epub 2015 Apr 3.
Fluorinated sulfinate salts RfSO2Na (Rf = CF2H, CF2Ph, and CH2F) have been prepared via NaBH4-mediated reduction of the corresponding benzo[d]thiazol-2-yl sulfones, and their synthetic application as di- and monofluoroalkyl radical precursors is demonstrated in the silver-catalyzed cascade fluoroalkylation/aryl migration/SO2 extrusion of conjugated N-arylsulfonylated amides.
全氟磺酸盐 RfSO2Na（Rf = CF2H、CF2Ph 和 CH2F）可通过 NaBH4 介导的相应苯并[d]噻唑-2-基砜还原来制备，并且它们作为二氟和单氟烷基自由基前体的合成应用在银催化的串联氟烷基化/芳基迁移/ SO2 脱除共轭 N-芳基磺酰胺中得到了证明。
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