一种构建二氟甲基取代的全碳季碳中心的简便方法：镍（II）催化的对映选择性迈克尔加成反应
A convenient approach to difluoromethylated all-carbon quaternary centers Ni(ii)-catalyzed enantioselective Michael addition.
作者信息
Yu Xuan, Bai Hui, Wang Dong, Qin Zhaohai, Li Jia-Qi, Fu Bin
机构信息
Department of Applied Chemistry, China Agricultural University West Yuanmingyuan Rd. 2 Beijing 100193 People's Republic of China
出版信息
RSC Adv. 2018 May 25;8(35):19402-19408. doi: 10.1039/c8ra02853b.
Abstract
A Ni(ii)-catalyzed enantioselective Michael addition of 2-acetyl azarenes with β-difluoromethyl substituted nitroalkenes was successfully realized, which afforded chiral CFH-containing compounds in good enantioselectivities (up to 93% ). This protocol provides a new convenient approach to all-carbon quaternary stereogenic centers featuring a CFH group.
摘要
成功实现了镍（II）催化的2-乙酰基氮杂芳烃与β-二氟甲基取代的硝基烯烃的对映选择性迈克尔加成反应，该反应以良好的对映选择性（高达93%）得到了含手性CFH的化合物。该方法为具有CFH基团的全碳季碳立体中心提供了一种新的便捷合成途径。
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