一种用于疏水性活性成分的细菌纤维素凝胶和纳米颗粒的缓释系统。
A slow-release system of bacterial cellulose gel and nanoparticles for hydrophobic active ingredients.
机构信息
Centre de Recherches sur les Macromoléculés Végétales (CERMAV, UPR-CNRS 5301), Université Grenoble Alpes, BP 53, F-38041 Grenoble Cedex 9, France; Department of Materials Chemistry, Asahikawa National College of Technology, Asahikawa 071-8142, Japan.
Centre de Recherches sur les Macromoléculés Végétales (CERMAV, UPR-CNRS 5301), Université Grenoble Alpes, BP 53, F-38041 Grenoble Cedex 9, France; Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis 88040-900, Brazil.
出版信息
Int J Pharm. 2015;486(1-2):217-25. doi: 10.1016/j.ijpharm.2015.03.068. Epub 2015 Mar 31.
A combination of bacterial cellulose (BC) gel and amphiphilic block copolymer nanoparticles was investigated as a drug delivery system (DDS) for hydrophobic active ingredients. Poly(ethylene oxide)-b-poly(caprolactone) (PEO-b-PCL) and retinol were used as the block copolymer and hydrophobic active ingredient, respectively. The BC gel was capable of incorporating copolymer nanoparticles and releasing them in an acetic acid-sodium acetate buffer solution (pH 5.2) at 37 °C. The percentage of released copolymer reached a maximum value of approximately 60% after 6h and remained constant after 24h. The percentage of retinol released from the copolymer-containing BC gel reached a maximum value at 4h. These results show that the combination of BC gel and nanoparticles is a slow-release system that may be useful in the cosmetic and biomedical fields for skin treatment and preparation.
研究了细菌纤维素 (BC) 凝胶与两亲嵌段共聚物纳米粒子的组合作为疏水性活性成分的药物传递系统 (DDS)。聚(环氧乙烷)-b-聚(己内酯) (PEO-b-PCL) 和视黄醇分别用作嵌段共聚物和疏水性活性成分。BC 凝胶能够掺入共聚物纳米粒子，并在 37°C 的乙酸-乙酸钠缓冲溶液 (pH 5.2) 中释放它们。在 6 小时后，释放的共聚物的百分比达到最大值约 60%，并且在 24 小时后保持不变。从含共聚物的 BC 凝胶中释放的视黄醇的百分比在 4 小时时达到最大值。这些结果表明，BC 凝胶和纳米粒子的组合是一种缓释系统，可能在皮肤治疗和制备的化妆品和生物医学领域中有用。
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