Maurice Roch L, Vaujois Laurence, Dahdah Nagib, Nuyt Anne-Monique, Bigras Jean-Luc
Service de Cardiologie, Centre Hospitalier Universitaire Sainte-Justine (CHUSJ), Université de Montréal, Montréal, Canada; Centre de Recherche, Centre Hospitalier Universitaire Sainte-Justine (CRCHUSJ), Université de Montréal, Montréal, Canada.
Service de Cardiologie, Centre Hospitalier Universitaire Sainte-Justine (CHUSJ), Université de Montréal, Montréal, Canada.
Ultrasound Med Biol. 2015 Jul;41(7):1808-13. doi: 10.1016/j.ultrasmedbio.2015.02.013. Epub 2015 Apr 1.
Arterial stiffness is a predictor of cardiovascular mortality. It increases with age and is accelerated by hypertension and other cardiovascular risk factors. In addition to the disease state, arterial stiffness increases from the proximal to the distal arterial compartments. Concurrent assessment of various vessels from the same subjects is unavailable in the literature. The aim of this work was to quantify an intrinsic mechanical feature, namely, wall stiffness, of the common carotid artery (CCA) and brachial artery (BA). CCAs and BAs of healthy adolescents were investigated. Cine loops of CCA and BA B-mode data were digitally recorded at the same clinical examination, and arterial elastic moduli were estimated off-line with our proprietary non-invasive Imaging-based BioMarker (ImBioMark) algorithm. The 11 study subjects were 14.4 ± 1.2 years old, with normal body habitus and blood pressures 112.3 ± 10.6/63.6 ± 5.7 mm Hg. BAs had a higher elastic modulus than CCAs (arterial elastic moduli: 129.73 ± 25.67 kPa vs. 49.55 ± 14.75 kPa, p < 0.001). There was a positive correlation between the BA and CCA (slope = 0.36, intercept = 111.62 kPa, R(2) = 0.045). This article documents, for the first time, a correlation between the CCA and BA of the same subject, under the same conditions. We previously reported preliminary data for the aorta and documented the effect of aging on the CCA; we now intend to study the femoral artery as well and include age stratification to pursue our investigations. The results reported here can be seen as the first step toward mechanical mapping of the arterial tree.
动脉僵硬度是心血管疾病死亡率的一个预测指标。它随年龄增长而增加，并因高血压和其他心血管危险因素而加速上升。除了疾病状态外，动脉僵硬度从近端到远端动脉节段也会增加。文献中尚无对同一受试者的不同血管进行同步评估的报道。本研究的目的是量化颈总动脉（CCA）和肱动脉（BA）的一种内在力学特征，即管壁僵硬度。对健康青少年的CCA和BA进行了研究。在同一次临床检查中对CCA和BA的B模式数据进行数字记录，并使用我们专有的基于成像的无创生物标志物（ImBioMark）算法离线估计动脉弹性模量。11名研究对象的年龄为14.4±1.2岁，身体状况正常，血压为112.3±10.6/63.6±5.7 mmHg。BA的弹性模量高于CCA（动脉弹性模量：129.73±25.67 kPa对49.55±14.75 kPa，p<0.001）。BA和CCA之间存在正相关（斜率=0.36，截距=111.62 kPa，R²=0.045）。本文首次记录了在相同条件下同一受试者的CCA和BA之间的相关性。我们之前报告了主动脉的初步数据，并记录了衰老对CCA的影响；我们现在打算对股动脉也进行研究，并纳入年龄分层以继续我们的研究。这里报告的结果可被视为动脉树力学图谱研究的第一步。
