Mikami T, Kurisu K, Kiya K, Mukada K, Kawamoto K, Hotta T, Uozumi T
Hiroshima J Med Sci. 1989 Sep;38(3):103-7.
We examined the antitumor effect of recombinant human lymphotoxin (rHuLT) on a xenotransplantable human malignant glioma line. Tumor-bearing nude mice were treated with rHuLT for three weeks following four schedules: intratumoral injection of rHuLT 20,000 units once a week, twice a week, intravenous injection once a week and twice a week. The inhibition rate of tumor growth was 98.8%, 99.1%, 92.1% and 98.8%, respectively. Histologically, necrotic lesions were observed in the tumors of all treated mice. Thrombo-obstructive changes of tumor vessels were also seen in the tumors of mice after intravenous injection of rHuLT. None of the mice died as a result of this treatment in spite of significant body weight loss. These results indicate that rHuLT has a strong antitumor effect on a xenotransplantable human malignant glioma line.
我们研究了重组人淋巴毒素（rHuLT）对一种可异种移植的人恶性胶质瘤细胞系的抗肿瘤作用。荷瘤裸鼠按照四种方案接受rHuLT治疗，为期三周：每周一次、每周两次瘤内注射20,000单位rHuLT，每周一次、每周两次静脉注射。肿瘤生长抑制率分别为98.8%、99.1%、92.1%和98.8%。组织学检查显示，所有接受治疗的小鼠肿瘤中均观察到坏死病变。静脉注射rHuLT后的小鼠肿瘤中也可见肿瘤血管的血栓阻塞性改变。尽管体重显著减轻，但没有一只小鼠因这种治疗而死亡。这些结果表明，rHuLT对一种可异种移植的人恶性胶质瘤细胞系具有强大的抗肿瘤作用。
